A rare case of pseudotumor formation associated with methyl methacrylate hypersensitivity in a patient following cemented total knee arthroplasty

Shachar Kenan, Leonard Kahn, Nogah Haramati, Samuel Kenan

Research output: Contribution to journalArticle

7 Scopus citations


Hypersensitivity to orthopedic implant materials has been well documented with potential catastrophic consequences if not addressed pre-operatively. The spectrum of reactions is wide, from mild non-specific pain with localized erythema to severe periprosthetic inflammatory destruction and pseudotumor formation. It is therefore essential to identify patients who have or are at risk for implant-associated hypersensitivity. Although metal sensitivity is commonly cited as the cause of these reactions, methyl methacrylate (MMA) has rarely been implicated. To the best of our knowledge, methyl methacrylate-associated pseudotumor formation has not yet been described. The following is a case report of a 68-year-old female who, after undergoing a routine cemented right total knee arthroplasty, developed a painless, enlarging mass during a 13-year period. This mass was found to be a pseudotumor in association with methyl methacrylate hypersensitivity. A review of pseudotumor pathogenesis, methyl methacrylate hypersensitivity, and preoperative preventative care is discussed.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalSkeletal Radiology
Publication statusAccepted/In press - Mar 29 2016



  • Allergy
  • Hypersensitivity
  • Methyl methacrylate
  • Pseudotumor
  • Total knee arthroplasty

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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