A randomized trial of levonorgestrel intrauterine system insertion 6 to 48 h compared to 6 weeks after vaginal delivery; Lessons learned

Gretchen S. Stuart, Catherine R. Lesko, Alison M. Stuebe, Amy G. Bryant, Erika E. Levi, Antoinette I. Danvers

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The objective of this randomized trial was to compare breastfeeding among women who received a levonorgestrel-releasing intrauterine system within 6-48 h (early) or 4-6 weeks (standard) after an uncomplicated vaginal birth. Analysis groups of 86 women in each arm were needed to demonstrate a 20% difference in any breastfeeding. Thirty-five women were randomized to the early (N= 17) and standard (N= 18) arms. The combination of unsuccessful placement (2/17; 12%), expulsions (7/17; 41%) and removals (3/17; 18%) reached 71% (12/17) in the early arm, so the study was stopped. In our small study cohort, levonorgestrel-releasing intrauterine system insertion between 6 and 48 h after vaginal birth was associated with a high rate of expulsion or removal soon after insertion.

Original languageEnglish (US)
Pages (from-to)284-288
Number of pages5
JournalContraception
Volume91
Issue number4
DOIs
StatePublished - Apr 1 2015

Keywords

  • Contraception
  • Family planning
  • Intrauterine device
  • Levonorgestrel
  • Postpartum

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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