A randomized trial comparing low-fat and low-carbohydrate diets matched for energy and protein.

C. J. Segal-Isaacson, Shannah Johnson, Vlad A. Tomuta, Brandy Cowell, Daniel T. Stein

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Several recent studies have found greater weight loss at 6 months among participants on a very-low-carbohydrate (VLC) weight-loss diet compared with a low-fat (LF) weight-loss diet. Because most of these studies were not matched for calories, it is not clear whether these results are caused by decreased energy intake or increased energy expenditure. It is hypothesized that several energy-consuming metabolic pathways are up-regulated during a VLC diet, leading to increased energy expenditure. The focus of this study was to investigate whether, when protein and energy are held constant, there is a significant difference in fat and weight loss when fat and carbohydrate are dramatically varied in the diet. The preliminary results presented in this paper are for the first four of six postmenopausal overweight or obese participants who followed, in random order, both a VLC and an LF diet for 6 weeks. Other outcome measures were serum lipids, glucose, and insulin, as well as dietary compliance and side effects. Our results showed no significant weight loss, lipid, serum insulin, or glucose differences between the two diets. Lipids were dramatically reduced on both diets, with a trend for greater triglyceride reduction on the VLC diet. Glucose levels were also reduced on both diets, with a trend for insulin reduction on the VLC diet. Compliance was excellent with both diets, and side effects were mild, although participants reported more food cravings and bad breath on the VLC diet and more burping and flatulence on the LF diet.

Original languageEnglish (US)
JournalObesity Research
Volume12 Suppl 2
StatePublished - Nov 2004

Fingerprint

Carbohydrate-Restricted Diet
low carbohydrate diet
Fats
Fat-Restricted Diet
Diet
weight loss
energy
Reducing Diet
lipids
Weight Loss
diet
Insulin
Proteins
Lipids
proteins
Glucose
Energy Metabolism
insulin
low fat diet
Carbohydrates

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Public Health, Environmental and Occupational Health
  • Endocrinology
  • Food Science
  • Endocrinology, Diabetes and Metabolism

Cite this

A randomized trial comparing low-fat and low-carbohydrate diets matched for energy and protein. / Segal-Isaacson, C. J.; Johnson, Shannah; Tomuta, Vlad A.; Cowell, Brandy; Stein, Daniel T.

In: Obesity Research, Vol. 12 Suppl 2, 11.2004.

Research output: Contribution to journalArticle

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