@article{286c5643e6924c3ab48d46ceefaa9f42,
title = "A prospective study of soluble receptor for advanced glycation end-products and colorectal cancer risk in postmenopausal women",
abstract = "Objectives: Receptor for advanced glycation end products (RAGE) expressed on adipocytes and immune cells can bind to ligand Nε-(carboxymethyl)-lysine (CML) and trigger dysregulation of adipokines and chronic inflammation. Soluble RAGE (sRAGE) mitigates the detrimental effect of RAGE. We examined the associations between circulating levels of CML-AGE and sRAGE and colorectal cancer (CRC). Methods: In a case-cohort study of the Women's Health Initiative Study, blood levels of CML-AGE and sRAGE were measured using ELISA. We used multivariable Cox regression model to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of incident CRC in relation to quartiles (Q) of biomarker levels. Results: Average follow-up was 7.8 years for 444 cases and 805 subcohort members. In the subcohort, CML-AGE and sRAGE were inversely correlated with BMI (P values < 0.0001). Levels of CML-AGE and sRAGE were not associated with CRC. In BMI-specific analysis, the association between sRAGE and CRC was observed. Among women with BMI ≥ 25 kg/m2, those with highest levels of sRAGE had significantly lower risk for CRC as compared to women with lowest levels of sRAGE (HRQ4 versus Q1: 0.39; 95% CI: 0.17-0.91). This inverse association was not observed among women with BMI <25 kg/m2 (P value for interaction = 0.01). Conclusions: Among postmenopausal women, the RAGE pathway may be involved in obesity-related CRC.",
keywords = "Advanced glycation end-products, Body weight, Colorectal cancer, Epidemiology, N-(carboxymethyl)-lysine, Obesity, Pattern recognition receptors, Receptor for advanced glycosylation end-products, SRAGE",
author = "Liang Chen and Zhigang Duan and Lesley Tinker and Haleh Sangi-Haghpeykar and Howard Strickler and Ho, {Gloria Y.F.} and Gunter, {Marc J.} and Thomas Rohan and Craig Logsdon and White, {Donna L.} and Kathryn Royse and El-Serag, {Hashem B.} and Li Jiao",
note = "Funding Information: This research was supported in part by the National Cancer Institute (5R03CA156626, PI: Jiao), the Dan L. Duncan Scholar Award, Gillson Longenbaugh Foundation, and Golfers Against Cancer organization (To L. Jiao); Texas Medical Center Digestive Disease Center (P30 DK56338); and Houston Veterans Affairs Health Services Research Center of Innovations (CIN13-413). The views expressed in this article are those of the authors and do not necessarily represent the views of the NCI and the Department of Veterans Affair or other funders. We acknowledge the dedicated efforts of investigators and staff at the Women{\textquoteright}s Health Initiative (WHI) clinical centers, the WHI Clinical Coordinating Center, and the National Heart, Lung and Blood program office (listing available at http://www.whi.org). We also recognize the WHI participants for their extraordinary commitment to the WHI program. For a list of all the investigators who have contributed to WHI science, please visit: http://www.whiscience.org/publications/WHI_investigators_longlist.pdf. The WHI program is funded by the National Heart, Lung, and Blood Institute, National Institutes of Health, US Department of Health and Human Services through contracts N01WH22110, 24152, 32100-2, 32105-6, 32108-9, 32111-13, 32115, 32118–32119, 32122, 42107-26, 42129-32, and 44221, and the Cancer Center Support Grant NIH:NCI P30CA022453. We thank Dr. Xiaonan Xue for statistical advice. Funding Information: This research was supported in part by the National Cancer Institute (5R03CA156626, PI: Jiao ), the Dan L. Duncan Scholar Award, Gillson Longenbaugh Foundation, and Golfers Against Cancer organization (To L. Jiao); Texas Medical Center Digestive Disease Center (P30 DK56338 ); and Houston Veterans Affairs Health Services Research Center of Innovations ( CIN13-413 ). The views expressed in this article are those of the authors and do not necessarily represent the views of the NCI and the Department of Veterans Affair or other funders. Funding Information: We acknowledge the dedicated efforts of investigators and staff at the Women⿿s Health Initiative (WHI) clinical centers, the WHI Clinical Coordinating Center, and the National Heart, Lung and Blood program office (listing available at http://www.whi.org ). We also recognize the WHI participants for their extraordinary commitment to the WHI program. For a list of all the investigators who have contributed to WHI science, please visit: http://www.whiscience.org/publications/WHI_investigators_longlist.pdf . The WHI program is funded by the National Heart, Lung, and Blood Institute, National Institutes of Health, US Department of Health and Human Services through contracts N01WH22110, 24152, 32100-2, 32105-6, 32108-9, 32111-13, 32115, 32118⿿32119, 32122, 42107-26, 42129-32, and 44221, and the Cancer Center Support Grant NIH:NCI P30CA022453. We thank Dr. Xiaonan Xue for statistical advice. Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd.",
year = "2016",
month = jun,
day = "1",
doi = "10.1016/j.canep.2016.04.004",
language = "English (US)",
volume = "42",
pages = "115--123",
journal = "Cancer Epidemiology",
issn = "1877-7821",
publisher = "Elsevier BV",
}
