A prospective study of recurrent febrile seizures

Anne T. Berg, Shlomo Shinnar, W. Allen Hauser, Marta Alemany, Eugene D. Shapiro, Morton E. Salomon, Ellen F. Crain

Research output: Contribution to journalArticle

193 Citations (Scopus)

Abstract

Background. Febrile seizures occur in 2 to 4 percent of all children, approximately one third of whom will have recurrent febrile seizures. Little is known about predictors of recurrence. Methods. In this prospective study, we identified 347 children (1 month to 10 years of age) who presented with a first febrile seizure at one of four pediatrie emergency departments. Information about these children was collected from medical records and interviews with the parents, and the children were followed for a median of 20 months to ascertain whether febrile seizures recurred. Results. Recurrent febrile seizures occurred in 94 of the 347 children (27 percent) with a cumulative risk of 25 percent at one year and 30 percent at two years. The duration of fever before the initial seizure was associated with the risk of recurrence at one year: for fever lasting less than 1 hour, the risk of recurrence was 44 percent; for fever lasting 1 to 24 hours, 23 percent; and for fever lasting more than 24 hours, 13 percent (P<0.001). With each degree of increase in temperature (in degrees Fahrenheit), from 101°F (38.3°C) to ≥105°F (40.6°C), the risk of recurrence at one year declined, from 35 percent to 30, 26, 20, and 13 percent (P for trend = 0.024). An age of less than 18 months and a family history of febrile seizures were also associated with an increased risk of recurrence. A family history of epilepsy, complex febrile seizures, and neurodevelopmental abnormalities did not increase the risk of recurrent febrile seizures. Conclusions. A shorter duration of fever before the initial febrile seizure and a lower temperature are associated with an increased risk of recurrence in children who have febrile seizures.

Original languageEnglish (US)
Pages (from-to)1122-1127
Number of pages6
JournalNew England Journal of Medicine
Volume327
Issue number16
StatePublished - Oct 15 1992

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Febrile Seizures
Prospective Studies
Fever
Recurrence
Temperature
Medical Records
Hospital Emergency Service
Epilepsy
Seizures
Parents
Interviews

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Berg, A. T., Shinnar, S., Hauser, W. A., Alemany, M., Shapiro, E. D., Salomon, M. E., & Crain, E. F. (1992). A prospective study of recurrent febrile seizures. New England Journal of Medicine, 327(16), 1122-1127.

A prospective study of recurrent febrile seizures. / Berg, Anne T.; Shinnar, Shlomo; Hauser, W. Allen; Alemany, Marta; Shapiro, Eugene D.; Salomon, Morton E.; Crain, Ellen F.

In: New England Journal of Medicine, Vol. 327, No. 16, 15.10.1992, p. 1122-1127.

Research output: Contribution to journalArticle

Berg, AT, Shinnar, S, Hauser, WA, Alemany, M, Shapiro, ED, Salomon, ME & Crain, EF 1992, 'A prospective study of recurrent febrile seizures', New England Journal of Medicine, vol. 327, no. 16, pp. 1122-1127.
Berg AT, Shinnar S, Hauser WA, Alemany M, Shapiro ED, Salomon ME et al. A prospective study of recurrent febrile seizures. New England Journal of Medicine. 1992 Oct 15;327(16):1122-1127.
Berg, Anne T. ; Shinnar, Shlomo ; Hauser, W. Allen ; Alemany, Marta ; Shapiro, Eugene D. ; Salomon, Morton E. ; Crain, Ellen F. / A prospective study of recurrent febrile seizures. In: New England Journal of Medicine. 1992 ; Vol. 327, No. 16. pp. 1122-1127.
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