A prospective study of leukocyte telomere length and risk of renal cell carcinoma

Jonathan N. Hofmann, Qing Lan, Richard Cawthon, Howard D. Hosgood, Brian Shuch, Lee E. Moore, Nathaniel Rothman, Wong Ho Chow, Mark P. Purdue

Research output: Contribution to journalArticle

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Abstract

Background: It has been hypothesized that genomic instability related to telomere dysfunction may contribute to carcinogenesis. There is some evidence from case-control studies suggesting that short leukocyte telomere length may be associated with an increased risk of renal cell carcinoma (RCC); however, this association has not been investigated prospectively. Methods: We conducted a nested case-control study (209 cases, 410 controls) of RCC risk in relation to prediagnostic leukocyte telomere length in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. ORs and 95% confidence intervals (CI) were estimated using conditional logistic regression. Results: Leukocyte telomere length was not significantly associated with future risk ofRCC(highest quartile vs. lowest: OR, 0.8; 95% CI, 0.5-1.5; Ptrend = 0.6). Analyses stratified by sex, age, and time from blood collection to RCC diagnosis were similarly null. Conclusions: The results of this study, to our knowledge the first prospective investigation of its kind, do not support an association between prediagnostic leukocyte telomere length and risk of RCC. Impact: In contrast to some earlier reports, our findings add to the evidence that leukocyte telomere length is not a biomarker of risk related to the etiology of RCC. Cancer Epidemiol Biomarkers Prev; 22(5); 997-1000.

Original languageEnglish (US)
Pages (from-to)997-1000
Number of pages4
JournalCancer Epidemiology Biomarkers and Prevention
Volume22
Issue number5
DOIs
StatePublished - May 2013

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Telomere
Renal Cell Carcinoma
Leukocytes
Prospective Studies
Case-Control Studies
Confidence Intervals
Genomic Instability
Tumor Biomarkers
Early Detection of Cancer
Ovarian Neoplasms
Colorectal Neoplasms
Lung Neoplasms
Prostatic Neoplasms
Carcinogenesis
Biomarkers
Logistic Models

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

A prospective study of leukocyte telomere length and risk of renal cell carcinoma. / Hofmann, Jonathan N.; Lan, Qing; Cawthon, Richard; Hosgood, Howard D.; Shuch, Brian; Moore, Lee E.; Rothman, Nathaniel; Chow, Wong Ho; Purdue, Mark P.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 22, No. 5, 05.2013, p. 997-1000.

Research output: Contribution to journalArticle

Hofmann, JN, Lan, Q, Cawthon, R, Hosgood, HD, Shuch, B, Moore, LE, Rothman, N, Chow, WH & Purdue, MP 2013, 'A prospective study of leukocyte telomere length and risk of renal cell carcinoma', Cancer Epidemiology Biomarkers and Prevention, vol. 22, no. 5, pp. 997-1000. https://doi.org/10.1158/1055-9965.EPI-13-0142
Hofmann, Jonathan N. ; Lan, Qing ; Cawthon, Richard ; Hosgood, Howard D. ; Shuch, Brian ; Moore, Lee E. ; Rothman, Nathaniel ; Chow, Wong Ho ; Purdue, Mark P. / A prospective study of leukocyte telomere length and risk of renal cell carcinoma. In: Cancer Epidemiology Biomarkers and Prevention. 2013 ; Vol. 22, No. 5. pp. 997-1000.
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