TY - JOUR
T1 - A prospective four-year follow-up of neuropsychological function in HIV seropositive and seronegative methadone-maintained patients
AU - Silberstein, Charles H.
AU - O'Dowd, Mary Alice
AU - Chartock, Patricia
AU - Schoenbaum, Ellie E.
AU - Friedland, Gerald
AU - Hartel, Diana
AU - McKegney, F. Patrick
N1 - Funding Information:
Work performed on this project was partially supported by CDC grant H64CCl-1200714
PY - 1993/11
Y1 - 1993/11
N2 - The evolution of central nervous system (CNS) impairments associated with human immunodeficiency virus (HIV) infection was assessed by a prospective, longitudinal study of patients in a methadone maintenance clinic. At a mean of 47 months after baseline testing, which included physical exams, HIV antibody testing and a neuropsychological (NP) screening battery, 121 subjects received a second NP assessment. Forty subjects (33%) who were seropositive at baseline showed statistically significant declines in NP function over the 4 years compared with 81 seronegatives, on the Finger Tapping and Trail Making B tests. This relatively long-term follow-up suggests that subtle cognitive deficits develop over time and can be identified early, but their course is slow and appears generally to parallel that of non-CNS symptoms/signs of HIV infection.
AB - The evolution of central nervous system (CNS) impairments associated with human immunodeficiency virus (HIV) infection was assessed by a prospective, longitudinal study of patients in a methadone maintenance clinic. At a mean of 47 months after baseline testing, which included physical exams, HIV antibody testing and a neuropsychological (NP) screening battery, 121 subjects received a second NP assessment. Forty subjects (33%) who were seropositive at baseline showed statistically significant declines in NP function over the 4 years compared with 81 seronegatives, on the Finger Tapping and Trail Making B tests. This relatively long-term follow-up suggests that subtle cognitive deficits develop over time and can be identified early, but their course is slow and appears generally to parallel that of non-CNS symptoms/signs of HIV infection.
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U2 - 10.1016/0163-8343(93)90001-5
DO - 10.1016/0163-8343(93)90001-5
M3 - Article
C2 - 8112557
AN - SCOPUS:0027772047
SN - 0163-8343
VL - 15
SP - 351
EP - 359
JO - General Hospital Psychiatry
JF - General Hospital Psychiatry
IS - 6
ER -
