A prospective four-year follow-up of neuropsychological function in HIV seropositive and seronegative methadone-maintained patients

Charles H. Silberstein, Mary A. O'Dowd, Patricia Chartock, Ellie Schoenbaum, Gerald Friedland, Diana Hartel, F. Patrick McKegney

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The evolution of central nervous system (CNS) impairments associated with human immunodeficiency virus (HIV) infection was assessed by a prospective, longitudinal study of patients in a methadone maintenance clinic. At a mean of 47 months after baseline testing, which included physical exams, HIV antibody testing and a neuropsychological (NP) screening battery, 121 subjects received a second NP assessment. Forty subjects (33%) who were seropositive at baseline showed statistically significant declines in NP function over the 4 years compared with 81 seronegatives, on the Finger Tapping and Trail Making B tests. This relatively long-term follow-up suggests that subtle cognitive deficits develop over time and can be identified early, but their course is slow and appears generally to parallel that of non-CNS symptoms/signs of HIV infection.

Original languageEnglish (US)
Pages (from-to)351-359
Number of pages9
JournalGeneral Hospital Psychiatry
Volume15
Issue number6
DOIs
StatePublished - 1993

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Methadone
HIV
Virus Diseases
Trail Making Test
Nervous System
Fingers
Signs and Symptoms
Longitudinal Studies
Central Nervous System
Prospective Studies
Antibodies

ASJC Scopus subject areas

  • Medicine(all)
  • Emergency Medicine
  • Psychiatry and Mental health

Cite this

A prospective four-year follow-up of neuropsychological function in HIV seropositive and seronegative methadone-maintained patients. / Silberstein, Charles H.; O'Dowd, Mary A.; Chartock, Patricia; Schoenbaum, Ellie; Friedland, Gerald; Hartel, Diana; McKegney, F. Patrick.

In: General Hospital Psychiatry, Vol. 15, No. 6, 1993, p. 351-359.

Research output: Contribution to journalArticle

Silberstein, Charles H. ; O'Dowd, Mary A. ; Chartock, Patricia ; Schoenbaum, Ellie ; Friedland, Gerald ; Hartel, Diana ; McKegney, F. Patrick. / A prospective four-year follow-up of neuropsychological function in HIV seropositive and seronegative methadone-maintained patients. In: General Hospital Psychiatry. 1993 ; Vol. 15, No. 6. pp. 351-359.
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