A prospective analysis of plasma endostatin levels in colorectal cancer patients with liver metastases

Andrew L. Feldman, H. Richard Alexander, David L. Bartlett, Karen C. Kranda, Marshall S. Miller, Nick G. Costouros, Peter L. Choyke, Steven K. Libutti

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

Background: Circulating inhibitors of angiogenesis have been suggested to affect the growth of distant micrometastatic disease in patients with cancer. This study was designed to evaluate circulating endostatin levels in colorectal cancer patients with liver metastases. Methods: Plasma samples from 30 colorectal cancer patients with liver metastases were analyzed for endostatin and vascular endothelial growth factor (VEGF) by using competitive enzyme immunoassays. Samples were compared with plasma from age- and sex-matched healthy controls; values >2 SD above the control mean were considered elevated. Results: Plasma endostatin levels were significantly higher in the 30 cancer patients than controls (P < .0001) and correlated with preoperative VEGF levels (P = .0008). Eighteen patients underwent surgical treatment (liver resection, n = 10; or isolated hepatic perfusion with melphalan, n = 8). Seventeen treated patients were available for follow-up. Eight of 11 patients who progressed had elevated plasma endostatin levels at the time of progression. None of six patients who remained progression free had elevated endostatin levels at last follow-up (P = .02). Conclusions: Plasma endostatin levels are elevated in colorectal cancer patients with liver metastases and correlate with VEGF levels. Elevated endostatin levels during follow-up are associated with disease progression. Understanding the role of endogenous endostatin in cancer patients may lead to novel strategies to inhibit tumor angiogenesis.

Original languageEnglish (US)
Pages (from-to)741-745
Number of pages5
JournalAnnals of Surgical Oncology
Volume8
Issue number9
DOIs
StatePublished - Oct 22 2001

Keywords

  • Angiogenesis
  • Colorectal cancer
  • Endostatin
  • Liver metastasis
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Surgery
  • Oncology

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    Feldman, A. L., Alexander, H. R., Bartlett, D. L., Kranda, K. C., Miller, M. S., Costouros, N. G., Choyke, P. L., & Libutti, S. K. (2001). A prospective analysis of plasma endostatin levels in colorectal cancer patients with liver metastases. Annals of Surgical Oncology, 8(9), 741-745. https://doi.org/10.1245/aso.2001.8.9.741