A primary encephalocele culture yields a pure population of human astrocytes

Ron L. Alterman, Richard S. Morrison, James T. Goodrich, Peter Papenhausen, Joseph R. Moskal

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

In order to develop a reliable source of human astrocytes for in vitro studies, we established a primary explant culture of a human encephalocele. This culture yielded a population of cells which were karyotypically normal, morphologically resembled astrocytes, expressed glial fibrillary acid protein, and responded mitogenically to exogenous growth factors. We conclude that white matter derived from human encephaloceles can be used to generate pure populations of normal astrocytes.

Original languageEnglish (US)
Pages (from-to)319-323
Number of pages5
JournalBrain research
Volume550
Issue number2
DOIs
StatePublished - Jun 7 1991

Keywords

  • Astrocyte
  • Encephalocele
  • Glia cell culture
  • Glial fibrillary acid protein
  • Growth factor

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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    Alterman, R. L., Morrison, R. S., Goodrich, J. T., Papenhausen, P., & Moskal, J. R. (1991). A primary encephalocele culture yields a pure population of human astrocytes. Brain research, 550(2), 319-323. https://doi.org/10.1016/0006-8993(91)91334-W