A PR-1-like protein of Fusarium oxysporum functions in virulence on mammalian hosts

Rafael C. Prados-Rosales, Raquel Roldán-Rodríguez, Carolina Serena, Manuel S. López-Berges, Josep Guarro, Álvaro Martínez-del-Pozo, Antonio Di Pietro

Research output: Contribution to journalArticle

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Abstract

The pathogenesis-related PR-1-like protein family comprises secreted proteins from the animal, plant, and fungal kingdoms whose biological function remains poorly understood. Here we have characterized a PR-1-like protein, Fpr1, from Fusarium oxysporum, an ubiquitous fungal pathogen that causes vascular wilt disease on a wide range of plant species and can produce life-threatening infections in immunocompromised humans. Fpr1 is secreted and proteolytically processed by the fungus. The fpr1 gene is required for virulence in a disseminated immunodepressed mouse model, and its function depends on the integrity of the proposed active site of PR-1-like proteins. Fpr1 belongs to a gene family that has expanded in plant pathogenic Sordariomycetes. These results suggest that secreted PR-1-like proteins play important roles in fungal pathogenicity.

Original languageEnglish (US)
Pages (from-to)21970-21979
Number of pages10
JournalJournal of Biological Chemistry
Volume287
Issue number26
DOIs
StatePublished - Jun 22 2012

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Fusarium
Virulence
Plant Proteins
Proteins
Fungal Proteins
Genes
Vascular Diseases
Catalytic Domain
Pathogens
Fungi
Animals
Infection

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Prados-Rosales, R. C., Roldán-Rodríguez, R., Serena, C., López-Berges, M. S., Guarro, J., Martínez-del-Pozo, Á., & Di Pietro, A. (2012). A PR-1-like protein of Fusarium oxysporum functions in virulence on mammalian hosts. Journal of Biological Chemistry, 287(26), 21970-21979. https://doi.org/10.1074/jbc.M112.364034

A PR-1-like protein of Fusarium oxysporum functions in virulence on mammalian hosts. / Prados-Rosales, Rafael C.; Roldán-Rodríguez, Raquel; Serena, Carolina; López-Berges, Manuel S.; Guarro, Josep; Martínez-del-Pozo, Álvaro; Di Pietro, Antonio.

In: Journal of Biological Chemistry, Vol. 287, No. 26, 22.06.2012, p. 21970-21979.

Research output: Contribution to journalArticle

Prados-Rosales, RC, Roldán-Rodríguez, R, Serena, C, López-Berges, MS, Guarro, J, Martínez-del-Pozo, Á & Di Pietro, A 2012, 'A PR-1-like protein of Fusarium oxysporum functions in virulence on mammalian hosts', Journal of Biological Chemistry, vol. 287, no. 26, pp. 21970-21979. https://doi.org/10.1074/jbc.M112.364034
Prados-Rosales RC, Roldán-Rodríguez R, Serena C, López-Berges MS, Guarro J, Martínez-del-Pozo Á et al. A PR-1-like protein of Fusarium oxysporum functions in virulence on mammalian hosts. Journal of Biological Chemistry. 2012 Jun 22;287(26):21970-21979. https://doi.org/10.1074/jbc.M112.364034
Prados-Rosales, Rafael C. ; Roldán-Rodríguez, Raquel ; Serena, Carolina ; López-Berges, Manuel S. ; Guarro, Josep ; Martínez-del-Pozo, Álvaro ; Di Pietro, Antonio. / A PR-1-like protein of Fusarium oxysporum functions in virulence on mammalian hosts. In: Journal of Biological Chemistry. 2012 ; Vol. 287, No. 26. pp. 21970-21979.
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