A potential propensity for failure secondary to clot embolism in neonatal ECMO

Espeed Khoshbin, David Machin, Hilliary Killer, Giles J. Peek, Andrzej W. Sosnowski, Richard K. Firmin

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: To report a single case of oxygenator failure caused by clot embolism originating from the bladder; and to discuss some preventative options. Case report: A 2.5 kg neonate with a diagnosis of influenza A received veno-arterial (V-A) extracorporeal membrane oxygenation (ECMO) for cardiorespiratory support. Halfway through treatment, she underwent an elective circuit change for numerous clots in her circuit. The patient continued to consume vast quantities of platelets and developed a fatal oxygenator failure after 18 days. Discussion: Amongst the factors influencing the outcome in events of a sudden unexpected oxygenator failure are the severity of patient illness, the size of the clot relative to the size of the oxygenator, the availability of a previously primed circuit and the ease and speed of priming a new oxygenator. Conclusion: There is a need for improvement in the design of small oxygenators and ECMO circuits. Adjustment of the coagulation parameters and lowering the tolerance towards clots in the circuit by electively changing them may reduce the incidence of sudden unexpected oxygenator failure. However, using a slightly larger Medos oxygenator may gain valuable time needed to arrange an oxygenator/circuit change.

Original languageEnglish (US)
Pages (from-to)177-181
Number of pages5
JournalPerfusion
Volume20
Issue number3
DOIs
StatePublished - 2005
Externally publishedYes

Fingerprint

Oxygenators
Extracorporeal Membrane Oxygenation
Oxygenation
Embolism
Membranes
Networks (circuits)
contagious disease
tolerance
incidence
illness
event
Platelets
Coagulation
Human Influenza
Urinary Bladder
Blood Platelets
Availability
Newborn Infant

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Khoshbin, E., Machin, D., Killer, H., Peek, G. J., Sosnowski, A. W., & Firmin, R. K. (2005). A potential propensity for failure secondary to clot embolism in neonatal ECMO. Perfusion, 20(3), 177-181. https://doi.org/10.1191/0267659105pf798cs

A potential propensity for failure secondary to clot embolism in neonatal ECMO. / Khoshbin, Espeed; Machin, David; Killer, Hilliary; Peek, Giles J.; Sosnowski, Andrzej W.; Firmin, Richard K.

In: Perfusion, Vol. 20, No. 3, 2005, p. 177-181.

Research output: Contribution to journalArticle

Khoshbin, E, Machin, D, Killer, H, Peek, GJ, Sosnowski, AW & Firmin, RK 2005, 'A potential propensity for failure secondary to clot embolism in neonatal ECMO', Perfusion, vol. 20, no. 3, pp. 177-181. https://doi.org/10.1191/0267659105pf798cs
Khoshbin, Espeed ; Machin, David ; Killer, Hilliary ; Peek, Giles J. ; Sosnowski, Andrzej W. ; Firmin, Richard K. / A potential propensity for failure secondary to clot embolism in neonatal ECMO. In: Perfusion. 2005 ; Vol. 20, No. 3. pp. 177-181.
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AU - Firmin, Richard K.

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