A potential link between p53, cell competition and ribosomopathy in mammals and in Drosophila

Nicholas E. Baker, Marianthi Kiparaki, Chaitali Khan

Research output: Contribution to journalArticle

Abstract

The term cell competition has been used to describe the phenomenon whereby particular cells can be eliminated during tissue growth only when more competitive cells are available to replace them. Multiple examples implicate differential activity of p53 in cell competition in mammals, but p53 has not been found to have the same role in Drosophila, where the phenomenon of cell competition was first recognized. Recent studies now show that Drosophila cells harboring mutations in Ribosomal protein (Rp) genes, which are eliminated by cell competition with wild type cells, activate a p53 target gene, Xrp1. In Diamond Blackfan Anemia, human Rp mutants activate p53 itself, through a nucleolar stress pathway. These results suggest a link between mammalian and Drosophila Rp mutants, translation, and cell competition.

Original languageEnglish (US)
JournalDevelopmental Biology
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Drosophila
Mammals
Ribosomal Proteins
Diamond-Blackfan Anemia
Drosophila Proteins
p53 Genes
Protein Biosynthesis
Mutation
Growth
Genes

Keywords

  • Cell competition
  • Diamond Blackfan Anemia
  • Minute
  • P53
  • Ribosomal protein

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

Cite this

A potential link between p53, cell competition and ribosomopathy in mammals and in Drosophila. / Baker, Nicholas E.; Kiparaki, Marianthi; Khan, Chaitali.

In: Developmental Biology, 01.01.2018.

Research output: Contribution to journalArticle

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