A possible mechanism of demyelination in the Syrian hamster with hindleg paralysis

A. Hirano

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Electron microscopic studies of the spinal roots and the sciatic nerves of mutant hamsters with hindleg paralysis and of similar age control animals are reported. Fibrillary accumulations, some of which showed a crystalloid organization, were found in the inner loops of the myelin sheath. These changes were severe in the mutant but only mild in the controls. Moreover, the mutant alone showed demyelination with apparent sparing of the Schwann cell perikaryon and subsequent remyelination. A possible mechanism relating the fibrillary accumulations to the demyelination is discussed.

Original languageEnglish (US)
Pages (from-to)115-121
Number of pages7
JournalLaboratory Investigation
Volume38
Issue number2
StatePublished - 1978

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Mesocricetus
Demyelinating Diseases
Paralysis
Spinal Nerve Roots
Schwann Cells
Sciatic Nerve
Myelin Sheath
Cricetinae
Electrons
crystalloid solutions

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

A possible mechanism of demyelination in the Syrian hamster with hindleg paralysis. / Hirano, A.

In: Laboratory Investigation, Vol. 38, No. 2, 1978, p. 115-121.

Research output: Contribution to journalArticle

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