A possible mechanism of demyelination in the Syrian hamster with hindleg paralysis

A. Hirano

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Electron microscopic studies of the spinal roots and the sciatic nerves of mutant hamsters with hindleg paralysis and of similar age control animals are reported. Fibrillary accumulations, some of which showed a crystalloid organization, were found in the inner loops of the myelin sheath. These changes were severe in the mutant but only mild in the controls. Moreover, the mutant alone showed demyelination with apparent sparing of the Schwann cell perikaryon and subsequent remyelination. A possible mechanism relating the fibrillary accumulations to the demyelination is discussed.

Original languageEnglish (US)
Pages (from-to)115-121
Number of pages7
JournalLaboratory Investigation
Volume38
Issue number2
StatePublished - Jan 1 1978

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

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