A porcine model of prolonged closed chest venovenous extracorporeal membrane oxygenation

Giles J. Peek, Richard Scott, Hilliary M. Killer, Martin A. Jarvis, Shyam Kolvekar, Derek Forbes, Richard K. Firmin

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The sheep has been the standard laboratory animal for extracorporeal membrane oxygenation (ECMO) research for many years and has proven to be an invaluable and reliable model. However the coagulation system of the sheep is significantly different from humans. These differences make it difficult to investigate the coagulative and inflammatory response to ECMO in sheep. The pig has a very similar coagulation system to humans and therefore makes a more appropriate model. We describe a porcine model of prolonged (48 hours) closed chest venovenous (VV) ECMO that we developed to investigate the inflammatory and coagulative response to different ECMO tubing materials. This model could be used to investigate any aspect of venovenous ECMO.

Original languageEnglish (US)
Pages (from-to)488-495
Number of pages8
JournalASAIO Journal
Volume45
Issue number5
StatePublished - Sep 1999
Externally publishedYes

Fingerprint

Extracorporeal Membrane Oxygenation
Oxygenation
Swine
Thorax
Membranes
Sheep
Coagulation
Laboratory Animals
Tubing
Animals
Research

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering

Cite this

Peek, G. J., Scott, R., Killer, H. M., Jarvis, M. A., Kolvekar, S., Forbes, D., & Firmin, R. K. (1999). A porcine model of prolonged closed chest venovenous extracorporeal membrane oxygenation. ASAIO Journal, 45(5), 488-495.

A porcine model of prolonged closed chest venovenous extracorporeal membrane oxygenation. / Peek, Giles J.; Scott, Richard; Killer, Hilliary M.; Jarvis, Martin A.; Kolvekar, Shyam; Forbes, Derek; Firmin, Richard K.

In: ASAIO Journal, Vol. 45, No. 5, 09.1999, p. 488-495.

Research output: Contribution to journalArticle

Peek, GJ, Scott, R, Killer, HM, Jarvis, MA, Kolvekar, S, Forbes, D & Firmin, RK 1999, 'A porcine model of prolonged closed chest venovenous extracorporeal membrane oxygenation', ASAIO Journal, vol. 45, no. 5, pp. 488-495.
Peek GJ, Scott R, Killer HM, Jarvis MA, Kolvekar S, Forbes D et al. A porcine model of prolonged closed chest venovenous extracorporeal membrane oxygenation. ASAIO Journal. 1999 Sep;45(5):488-495.
Peek, Giles J. ; Scott, Richard ; Killer, Hilliary M. ; Jarvis, Martin A. ; Kolvekar, Shyam ; Forbes, Derek ; Firmin, Richard K. / A porcine model of prolonged closed chest venovenous extracorporeal membrane oxygenation. In: ASAIO Journal. 1999 ; Vol. 45, No. 5. pp. 488-495.
@article{89f965adb4f846aebcdf76ca4cceb017,
title = "A porcine model of prolonged closed chest venovenous extracorporeal membrane oxygenation",
abstract = "The sheep has been the standard laboratory animal for extracorporeal membrane oxygenation (ECMO) research for many years and has proven to be an invaluable and reliable model. However the coagulation system of the sheep is significantly different from humans. These differences make it difficult to investigate the coagulative and inflammatory response to ECMO in sheep. The pig has a very similar coagulation system to humans and therefore makes a more appropriate model. We describe a porcine model of prolonged (48 hours) closed chest venovenous (VV) ECMO that we developed to investigate the inflammatory and coagulative response to different ECMO tubing materials. This model could be used to investigate any aspect of venovenous ECMO.",
author = "Peek, {Giles J.} and Richard Scott and Killer, {Hilliary M.} and Jarvis, {Martin A.} and Shyam Kolvekar and Derek Forbes and Firmin, {Richard K.}",
year = "1999",
month = "9",
language = "English (US)",
volume = "45",
pages = "488--495",
journal = "ASAIO journal (American Society for Artificial Internal Organs : 1992)",
issn = "1058-2916",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - A porcine model of prolonged closed chest venovenous extracorporeal membrane oxygenation

AU - Peek, Giles J.

AU - Scott, Richard

AU - Killer, Hilliary M.

AU - Jarvis, Martin A.

AU - Kolvekar, Shyam

AU - Forbes, Derek

AU - Firmin, Richard K.

PY - 1999/9

Y1 - 1999/9

N2 - The sheep has been the standard laboratory animal for extracorporeal membrane oxygenation (ECMO) research for many years and has proven to be an invaluable and reliable model. However the coagulation system of the sheep is significantly different from humans. These differences make it difficult to investigate the coagulative and inflammatory response to ECMO in sheep. The pig has a very similar coagulation system to humans and therefore makes a more appropriate model. We describe a porcine model of prolonged (48 hours) closed chest venovenous (VV) ECMO that we developed to investigate the inflammatory and coagulative response to different ECMO tubing materials. This model could be used to investigate any aspect of venovenous ECMO.

AB - The sheep has been the standard laboratory animal for extracorporeal membrane oxygenation (ECMO) research for many years and has proven to be an invaluable and reliable model. However the coagulation system of the sheep is significantly different from humans. These differences make it difficult to investigate the coagulative and inflammatory response to ECMO in sheep. The pig has a very similar coagulation system to humans and therefore makes a more appropriate model. We describe a porcine model of prolonged (48 hours) closed chest venovenous (VV) ECMO that we developed to investigate the inflammatory and coagulative response to different ECMO tubing materials. This model could be used to investigate any aspect of venovenous ECMO.

UR - http://www.scopus.com/inward/record.url?scp=0033200926&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033200926&partnerID=8YFLogxK

M3 - Article

C2 - 10503631

AN - SCOPUS:0033200926

VL - 45

SP - 488

EP - 495

JO - ASAIO journal (American Society for Artificial Internal Organs : 1992)

JF - ASAIO journal (American Society for Artificial Internal Organs : 1992)

SN - 1058-2916

IS - 5

ER -