A pooled analysis of 14 cohort studies of anthropometric factors and pancreatic cancer risk

Jeanine M. Genkinger, Donna Spiegelman, Kristin E. Anderson, Leslie Bernstein, Piet A. Van Den Brandt, Eugenia E. Calle, Dallas R. English, Aaron R. Folsom, Jo L. Freudenheim, Charles S. Fuchs, Graham G. Giles, Edward Giovannucci, Pamela L. Horn-Ross, Susanna C. Larsson, Michael Leitzmann, Satu Männistö, James R. Marshall, Anthony B. Miller, Alpa V. Patel, Thomas E. Rohan & 7 others Rachael Z. Stolzenberg-Solomon, Bas Aj Verhage, Jarmo Virtamo, Bradley J. Willcox, Alicja Wolk, Regina G. Ziegler, Stephanie A. Smith-Warner

Research output: Contribution to journalArticle

127 Citations (Scopus)

Abstract

Epidemiologic studies of pancreatic cancer risk have reported null or nonsignificant positive associations for obesity, while associations for height have been null. Waist and hip circumference have been evaluated infrequently. A pooled analysis of 14 cohort studies on 846,340 individuals was conducted; 2,135 individuals were diagnosed with pancreatic cancer during follow-up. Study-specific relative risks (RRs) and 95% confidence intervals (CIs) were calculated by Cox proportional hazards models, and then pooled using a random effects model. Compared to individuals with a body mass index (BMI) at baseline between 21-22.9 kg/m2, pancreatic cancer risk was 47% higher (95%CI:23-75%) among obese (BMI ≤yen; 30 kg/m2) individuals. A positive association was observed for BMI in early adulthood (pooled multivariate [MV]RR = 1.30, 95%CI = 1.09-1.56 comparing BMI ≤yen; 25 kg/m2 to a BMI between 21 and 22.9 kg/m2). Compared to individuals who were not overweight in early adulthood (BMI < 25 kg/m 2) and not obese at baseline (BMI < 30 kg/m2), pancreatic cancer risk was 54% higher (95%CI = 24-93%) for those who were overweight in early adulthood and obese at baseline. We observed a 40% higher risk among individuals who had gained BMI ≤yen; 10 kg/m2 between BMI at baseline and younger ages compared to individuals whose BMI remained stable. Results were either similar or slightly stronger among never smokers. A positive association was observed between waist to hip ratio (WHR) and pancreatic cancer risk (pooled MVRR = 1.35 comparing the highest versus lowest quartile, 95%CI = 1.03-1.78). BMI and WHR were positively associated with pancreatic cancer risk. Maintaining normal body weight may offer a feasible approach to reducing morbidity and mortality from pancreatic cancer.

Original languageEnglish (US)
Pages (from-to)1708-1717
Number of pages10
JournalInternational Journal of Cancer
Volume129
Issue number7
DOIs
StatePublished - Oct 1 2011

Fingerprint

Pancreatic Neoplasms
Body Mass Index
Cohort Studies
Confidence Intervals
Waist-Hip Ratio
Ideal Body Weight
Waist Circumference
Proportional Hazards Models
Hip
Epidemiologic Studies
Obesity
Morbidity
Mortality

Keywords

  • anthropometry
  • deceased
  • pancreatic cancer
  • pooled analysis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Genkinger, J. M., Spiegelman, D., Anderson, K. E., Bernstein, L., Van Den Brandt, P. A., Calle, E. E., ... Smith-Warner, S. A. (2011). A pooled analysis of 14 cohort studies of anthropometric factors and pancreatic cancer risk. International Journal of Cancer, 129(7), 1708-1717. https://doi.org/10.1002/ijc.25794

A pooled analysis of 14 cohort studies of anthropometric factors and pancreatic cancer risk. / Genkinger, Jeanine M.; Spiegelman, Donna; Anderson, Kristin E.; Bernstein, Leslie; Van Den Brandt, Piet A.; Calle, Eugenia E.; English, Dallas R.; Folsom, Aaron R.; Freudenheim, Jo L.; Fuchs, Charles S.; Giles, Graham G.; Giovannucci, Edward; Horn-Ross, Pamela L.; Larsson, Susanna C.; Leitzmann, Michael; Männistö, Satu; Marshall, James R.; Miller, Anthony B.; Patel, Alpa V.; Rohan, Thomas E.; Stolzenberg-Solomon, Rachael Z.; Verhage, Bas Aj; Virtamo, Jarmo; Willcox, Bradley J.; Wolk, Alicja; Ziegler, Regina G.; Smith-Warner, Stephanie A.

In: International Journal of Cancer, Vol. 129, No. 7, 01.10.2011, p. 1708-1717.

Research output: Contribution to journalArticle

Genkinger, JM, Spiegelman, D, Anderson, KE, Bernstein, L, Van Den Brandt, PA, Calle, EE, English, DR, Folsom, AR, Freudenheim, JL, Fuchs, CS, Giles, GG, Giovannucci, E, Horn-Ross, PL, Larsson, SC, Leitzmann, M, Männistö, S, Marshall, JR, Miller, AB, Patel, AV, Rohan, TE, Stolzenberg-Solomon, RZ, Verhage, BA, Virtamo, J, Willcox, BJ, Wolk, A, Ziegler, RG & Smith-Warner, SA 2011, 'A pooled analysis of 14 cohort studies of anthropometric factors and pancreatic cancer risk', International Journal of Cancer, vol. 129, no. 7, pp. 1708-1717. https://doi.org/10.1002/ijc.25794
Genkinger JM, Spiegelman D, Anderson KE, Bernstein L, Van Den Brandt PA, Calle EE et al. A pooled analysis of 14 cohort studies of anthropometric factors and pancreatic cancer risk. International Journal of Cancer. 2011 Oct 1;129(7):1708-1717. https://doi.org/10.1002/ijc.25794
Genkinger, Jeanine M. ; Spiegelman, Donna ; Anderson, Kristin E. ; Bernstein, Leslie ; Van Den Brandt, Piet A. ; Calle, Eugenia E. ; English, Dallas R. ; Folsom, Aaron R. ; Freudenheim, Jo L. ; Fuchs, Charles S. ; Giles, Graham G. ; Giovannucci, Edward ; Horn-Ross, Pamela L. ; Larsson, Susanna C. ; Leitzmann, Michael ; Männistö, Satu ; Marshall, James R. ; Miller, Anthony B. ; Patel, Alpa V. ; Rohan, Thomas E. ; Stolzenberg-Solomon, Rachael Z. ; Verhage, Bas Aj ; Virtamo, Jarmo ; Willcox, Bradley J. ; Wolk, Alicja ; Ziegler, Regina G. ; Smith-Warner, Stephanie A. / A pooled analysis of 14 cohort studies of anthropometric factors and pancreatic cancer risk. In: International Journal of Cancer. 2011 ; Vol. 129, No. 7. pp. 1708-1717.
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