A pool of native alpha-chains in guinea pig reticulocytes

T. Campana, Simeon Pollack, R. L. Nagel

Research output: Contribution to journalArticle

Abstract

Five radioactive peaks can be identified when hemolysates prepared from 59Fe-labelled guinea pig reticlocytes are subjected to molecular sieve chromatography. The third peak, hemoglobin, is followed by another hemi-containing peak eluting with an apparent molecular weight of 17,000. We now demonstrate that this 17,000 MW peak consists of α-chains. The high specific activity (59Fe/heme) of these α-chains suggests that they may be the primary site of heme entry into the hemoglobin molecule.

Original languageEnglish (US)
Pages (from-to)190-193
Number of pages4
JournalActa Haematologica
Volume67
Issue number3
StatePublished - 1982

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Reticulocytes
Heme
Guinea Pigs
Hemoglobins
Gel Chromatography
Molecular Weight

ASJC Scopus subject areas

  • Hematology

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Campana, T., Pollack, S., & Nagel, R. L. (1982). A pool of native alpha-chains in guinea pig reticulocytes. Acta Haematologica, 67(3), 190-193.

A pool of native alpha-chains in guinea pig reticulocytes. / Campana, T.; Pollack, Simeon; Nagel, R. L.

In: Acta Haematologica, Vol. 67, No. 3, 1982, p. 190-193.

Research output: Contribution to journalArticle

Campana, T, Pollack, S & Nagel, RL 1982, 'A pool of native alpha-chains in guinea pig reticulocytes', Acta Haematologica, vol. 67, no. 3, pp. 190-193.
Campana T, Pollack S, Nagel RL. A pool of native alpha-chains in guinea pig reticulocytes. Acta Haematologica. 1982;67(3):190-193.
Campana, T. ; Pollack, Simeon ; Nagel, R. L. / A pool of native alpha-chains in guinea pig reticulocytes. In: Acta Haematologica. 1982 ; Vol. 67, No. 3. pp. 190-193.
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