A pneumococcal capsular polysaccharide vaccine induces a repertoire shift with increased V(H)3 expression in peripheral B cells from human immunodeficiency virus (HIV)-uninfected but not HIV-infected persons

Q. Chang, J. Abadi, P. Alpert, Liise anne Pirofski

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

The molecular mechanism of pneumococcal vaccine failure in human immunodeficiency virus (HIV)-infected persons is not fully understood. A polymerase chain reaction ELISA was used to determine the proportion of peripheral IgG, IgA, and IgM CD19-positive B cells expressing 6 immunoglobulin heavy-chain variable region (V(H)) subgroups before and 7 days after pneumococcal vaccination of 12 HIV-infected and 12 HIV-uninfected subjects. Significant postvaccination increases in the expression of the V(H)3 subgroup by IgG and IgA and a greater serologic response to vaccination were observed in the HIV-uninfected group. In contrast, the HIV-infected group had reduced prevaccination IgG V(H)3 and a postvaccination increase in IgG V(H)5. These results demonstrate that pneumococcal vaccination changes the pattern of B cell V(H) gene expression and support the concept that aberrant V(H)3 expression may translate into a poor antipneumococcal response in the setting of HIV infection.

Original languageEnglish (US)
Pages (from-to)1313-1321
Number of pages9
JournalJournal of Infectious Diseases
Volume181
Issue number4
DOIs
StatePublished - May 22 2000

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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