A pilot study of low-cost, high-resolution microendoscopy as a tool for identifying women with cervical precancer

Mark C. Pierce, YaoYao Guan, Mary Kate Quinn, Xun Zhang, Wen Hua Zhang, You Lin Qiao, Philip E. Castle, Rebecca Richards-Kortum

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Cervical cancer remains one of the leading causes of death among women in developing countries. Without resources to support Pap smear cytology and colposcopy, cost-effective approaches which enable single-visit "see-and-treat" protocols offer the potential to reduce morbidity and mortality due to this preventable disease. We carried out a pilot clinical study in Shanxi province, China, to evaluate a low-cost, high-resolution microendoscope (HRME) imaging system which enables evaluation of epithelial cell morphology in vivo. HRME images were obtained at discrete sites on the cervix in 174 women, in addition to visual inspection with acetic acid (VIA) and colposcopic examination. Of 69 sites appearing abnormal on colposcopy, only 12 showed high-grade disease (CIN2+) on pathology. Quantification of the nuclear-to-cytoplasm ratio by HRME enabled an ad hoc threshold to be defined, which correctly classified all 12 sites as abnormal, whilst classifying 38 of the remaining 57 pathology normal sites as normal. All patients with biopsy confirmed high-grade disease also tested positive for high-risk human papilloma virus (HPV) DNA and were classified as abnormal by HRME. Among the remaining patients who tested positive for HPV but were either normal by colposcopy or showed <CIN2 on pathology, only 6 of 32 (18.8%) were classified as abnormal by HRME. Visual examination techniques for cervical cancer screening may overestimate the prevalence of precancerous lesions, leading to unnecessary treatment, expense, and patient stress. The results of this study suggest that evaluation of suspicious lesions by HRME may assist in ruling out immediate cryotherapy, thus increasing the efficiency of current see-and-treat programs.

Original languageEnglish (US)
Pages (from-to)1273-1279
Number of pages7
JournalCancer Prevention Research
Volume5
Issue number11
DOIs
StatePublished - Nov 2012

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Papillomaviridae
Colposcopy
Pathology
Costs and Cost Analysis
Uterine Cervical Neoplasms
Papanicolaou Test
Cryotherapy
Early Detection of Cancer
Cervix Uteri
Acetic Acid
Developing Countries
Cell Biology
Cause of Death
China
Cytoplasm
Epithelial Cells
Morbidity
Biopsy
Mortality
DNA

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Pierce, M. C., Guan, Y., Quinn, M. K., Zhang, X., Zhang, W. H., Qiao, Y. L., ... Richards-Kortum, R. (2012). A pilot study of low-cost, high-resolution microendoscopy as a tool for identifying women with cervical precancer. Cancer Prevention Research, 5(11), 1273-1279. https://doi.org/10.1158/1940-6207.CAPR-12-0221

A pilot study of low-cost, high-resolution microendoscopy as a tool for identifying women with cervical precancer. / Pierce, Mark C.; Guan, YaoYao; Quinn, Mary Kate; Zhang, Xun; Zhang, Wen Hua; Qiao, You Lin; Castle, Philip E.; Richards-Kortum, Rebecca.

In: Cancer Prevention Research, Vol. 5, No. 11, 11.2012, p. 1273-1279.

Research output: Contribution to journalArticle

Pierce, Mark C. ; Guan, YaoYao ; Quinn, Mary Kate ; Zhang, Xun ; Zhang, Wen Hua ; Qiao, You Lin ; Castle, Philip E. ; Richards-Kortum, Rebecca. / A pilot study of low-cost, high-resolution microendoscopy as a tool for identifying women with cervical precancer. In: Cancer Prevention Research. 2012 ; Vol. 5, No. 11. pp. 1273-1279.
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