A pilot study of antitumor effect of gallium ethylenediaminetetramethylene phosphonate [Ga(III)-EDTMP] in tumor-bearing rats

Mingming Su, Yunping Qiu, Wei Jia

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The inhibitory effects of gallium ethylenediamine-N,N,N′,N′- tetrakismethylene phosphonate [Ga(III)-EDTMP] was studied on a malignant tumor and metastatic bone lesion model induced with Walker carcinosarcoma 256 (WCS 256) in Wistar rats weighing 120 to 135 g. A water-soluble chelate, Ga(III)-EDTMP, was prepared for injection in a tumor-bearing model. Radiographic analysis at 14 days indicated that the bone invasion and osteolysis were markedly reduced in animals treated with Ga(III)-EDTMP. The calculated tumor inhibitory rates were 33.16±0.38% at a dosage of 5 mg/kg and 47.75±0.74% at 10 mg/kg. Biochemical markers such as serum calcium decreased by 23% (P<.05) and by 31% (P<.01) at dosages of 5 mg/kg and 10 mg/kg, respectively, whereas serum alkaline phosphatase (ALPase) activity decreased by 47% (P<.01) and 69% (P<.01) at the 2 dosages.

Original languageEnglish (US)
Pages (from-to)297-306
Number of pages10
JournalAdvances in Therapy
Volume22
Issue number4
DOIs
StatePublished - Jul 2005
Externally publishedYes

Keywords

  • Bone metastasis
  • Ga(III)-EDTMP
  • Gallium ethylenediaminetetramethylene phosphonate
  • Inhibitory rate
  • Osteolysis

ASJC Scopus subject areas

  • Pharmacology (medical)

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