A pilot study of antitumor effect of gallium ethylenediaminetetramethylene phosphonate [Ga(III)-EDTMP] in tumor-bearing rats

Mingming Su, Yunping Qiu, Wei Jia

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The inhibitory effects of gallium ethylenediamine-N,N,N′,N′- tetrakismethylene phosphonate [Ga(III)-EDTMP] was studied on a malignant tumor and metastatic bone lesion model induced with Walker carcinosarcoma 256 (WCS 256) in Wistar rats weighing 120 to 135 g. A water-soluble chelate, Ga(III)-EDTMP, was prepared for injection in a tumor-bearing model. Radiographic analysis at 14 days indicated that the bone invasion and osteolysis were markedly reduced in animals treated with Ga(III)-EDTMP. The calculated tumor inhibitory rates were 33.16±0.38% at a dosage of 5 mg/kg and 47.75±0.74% at 10 mg/kg. Biochemical markers such as serum calcium decreased by 23% (P<.05) and by 31% (P<.01) at dosages of 5 mg/kg and 10 mg/kg, respectively, whereas serum alkaline phosphatase (ALPase) activity decreased by 47% (P<.01) and 69% (P<.01) at the 2 dosages.

Original languageEnglish (US)
Pages (from-to)297-306
Number of pages10
JournalAdvances in Therapy
Volume22
Issue number4
DOIs
StatePublished - Jul 2005
Externally publishedYes

Fingerprint

Organophosphonates
Gallium
ethylenediamine
Walker Carcinoma 256
Bone and Bones
Neoplasms
Osteolysis
Serum
Alkaline Phosphatase
Wistar Rats
Biomarkers
Calcium
Injections
Water

Keywords

  • Bone metastasis
  • Ga(III)-EDTMP
  • Gallium ethylenediaminetetramethylene phosphonate
  • Inhibitory rate
  • Osteolysis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A pilot study of antitumor effect of gallium ethylenediaminetetramethylene phosphonate [Ga(III)-EDTMP] in tumor-bearing rats. / Su, Mingming; Qiu, Yunping; Jia, Wei.

In: Advances in Therapy, Vol. 22, No. 4, 07.2005, p. 297-306.

Research output: Contribution to journalArticle

@article{a572133a048643ada83f13f419193e87,
title = "A pilot study of antitumor effect of gallium ethylenediaminetetramethylene phosphonate [Ga(III)-EDTMP] in tumor-bearing rats",
abstract = "The inhibitory effects of gallium ethylenediamine-N,N,N′,N′- tetrakismethylene phosphonate [Ga(III)-EDTMP] was studied on a malignant tumor and metastatic bone lesion model induced with Walker carcinosarcoma 256 (WCS 256) in Wistar rats weighing 120 to 135 g. A water-soluble chelate, Ga(III)-EDTMP, was prepared for injection in a tumor-bearing model. Radiographic analysis at 14 days indicated that the bone invasion and osteolysis were markedly reduced in animals treated with Ga(III)-EDTMP. The calculated tumor inhibitory rates were 33.16±0.38{\%} at a dosage of 5 mg/kg and 47.75±0.74{\%} at 10 mg/kg. Biochemical markers such as serum calcium decreased by 23{\%} (P<.05) and by 31{\%} (P<.01) at dosages of 5 mg/kg and 10 mg/kg, respectively, whereas serum alkaline phosphatase (ALPase) activity decreased by 47{\%} (P<.01) and 69{\%} (P<.01) at the 2 dosages.",
keywords = "Bone metastasis, Ga(III)-EDTMP, Gallium ethylenediaminetetramethylene phosphonate, Inhibitory rate, Osteolysis",
author = "Mingming Su and Yunping Qiu and Wei Jia",
year = "2005",
month = "7",
doi = "10.1007/BF02850079",
language = "English (US)",
volume = "22",
pages = "297--306",
journal = "Advances in Therapy",
issn = "0741-238X",
publisher = "Health Communications Inc.",
number = "4",

}

TY - JOUR

T1 - A pilot study of antitumor effect of gallium ethylenediaminetetramethylene phosphonate [Ga(III)-EDTMP] in tumor-bearing rats

AU - Su, Mingming

AU - Qiu, Yunping

AU - Jia, Wei

PY - 2005/7

Y1 - 2005/7

N2 - The inhibitory effects of gallium ethylenediamine-N,N,N′,N′- tetrakismethylene phosphonate [Ga(III)-EDTMP] was studied on a malignant tumor and metastatic bone lesion model induced with Walker carcinosarcoma 256 (WCS 256) in Wistar rats weighing 120 to 135 g. A water-soluble chelate, Ga(III)-EDTMP, was prepared for injection in a tumor-bearing model. Radiographic analysis at 14 days indicated that the bone invasion and osteolysis were markedly reduced in animals treated with Ga(III)-EDTMP. The calculated tumor inhibitory rates were 33.16±0.38% at a dosage of 5 mg/kg and 47.75±0.74% at 10 mg/kg. Biochemical markers such as serum calcium decreased by 23% (P<.05) and by 31% (P<.01) at dosages of 5 mg/kg and 10 mg/kg, respectively, whereas serum alkaline phosphatase (ALPase) activity decreased by 47% (P<.01) and 69% (P<.01) at the 2 dosages.

AB - The inhibitory effects of gallium ethylenediamine-N,N,N′,N′- tetrakismethylene phosphonate [Ga(III)-EDTMP] was studied on a malignant tumor and metastatic bone lesion model induced with Walker carcinosarcoma 256 (WCS 256) in Wistar rats weighing 120 to 135 g. A water-soluble chelate, Ga(III)-EDTMP, was prepared for injection in a tumor-bearing model. Radiographic analysis at 14 days indicated that the bone invasion and osteolysis were markedly reduced in animals treated with Ga(III)-EDTMP. The calculated tumor inhibitory rates were 33.16±0.38% at a dosage of 5 mg/kg and 47.75±0.74% at 10 mg/kg. Biochemical markers such as serum calcium decreased by 23% (P<.05) and by 31% (P<.01) at dosages of 5 mg/kg and 10 mg/kg, respectively, whereas serum alkaline phosphatase (ALPase) activity decreased by 47% (P<.01) and 69% (P<.01) at the 2 dosages.

KW - Bone metastasis

KW - Ga(III)-EDTMP

KW - Gallium ethylenediaminetetramethylene phosphonate

KW - Inhibitory rate

KW - Osteolysis

UR - http://www.scopus.com/inward/record.url?scp=29344466927&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=29344466927&partnerID=8YFLogxK

U2 - 10.1007/BF02850079

DO - 10.1007/BF02850079

M3 - Article

VL - 22

SP - 297

EP - 306

JO - Advances in Therapy

JF - Advances in Therapy

SN - 0741-238X

IS - 4

ER -