Abstract
Thirteen patients with accelerated phase of chronic myeloid leukemia (CML-AC) were treated with intravenous plicamycin and subcutaneous alpha-interferon. Two patients stabilized, three patients had partial hematologic responses and one patient had a hematologic complete response with a major cytogenetic response. Two patients, progressing on hydroxyurea, did not respond, but demonstrated re-sensitization to hydroxyurea after completion of induction therapy and had prolonged return to chronic phase for 30 months and 25 months. Four non-responders subsequently received additional chemotherapy and responded. Median survival of all study patients from the development of accelerated phase of CML was 24 months: substantially longer than other reported series (median 6 months). Plicamycin appears to add efficacy to interferon in the stabilization of accelerated phase of CML.
Original language | English (US) |
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Pages (from-to) | 375-380 |
Number of pages | 6 |
Journal | Leukemia Research |
Volume | 21 |
Issue number | 5 |
DOIs | |
State | Published - May 1997 |
Keywords
- Accelerated phase CML
- Chronic myeloid leukemia (CML)
- Interferon
- Leukemia
- Plicamycin
- Therapy-CML
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research