Background: This was a two-stage, phase II trial of the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor BEZ235 in patients with everolimusresistant pancreatic neuroendocrine tumours (pNETs) (NCT01658436). Patients and Methods: In stage 1, 11 patients received 400 mg BEZ235 orally twice daily (bid). Due to tolerability concerns, a further 20 patients received BEZ235 300 mg bid. Stage 2 would be triggered by a 16-week progressionfree survival (PFS) rate of =60% in stage 1. Results: As of 30 June, 2014, 29/31 patients had discontinued treatment. Treatment-related grade 3/4 adverse events were reported in eight (72.7%) patients at 400 mg and eight (40.0%) patients at 300 mg, including hyperglycaemia, diarrhoea, nausea, and vomiting. The estimated 16-week PFS rate was 51.6% (90% confidence interval=35.7-67.3%). Conclusion: BEZ235 was poorly tolerated by patients with everolimus-resistant pNETs at 400 and 300 mg bid doses. Although evidence of disease stability was observed, the study did not proceed to stage 2. Pancreatic neuroendocrine tumours (pNETs) are rare malignancies, representing <2% of all pancreatic cancers (1). Several studies suggest that the annual incidence of pNETs, currently reported to be less than one in 100,000, is rising (1-4). pNETs tend to be slow-growing or indolent compared to other types of cancer, such as pancreatic adenocarcinoma, making early detection difficult. Most patients present with metastatic disease and have a poor prognosis, despite the increasing availability of treatment options (4).
|Original language||English (US)|
|Number of pages||8|
|State||Published - Feb 2016|
ASJC Scopus subject areas
- Cancer Research