A phase 2 study of radio frequency interstitial tissue ablation of localized renal tumors

McClellan M. Walther, Thomas H. Shawker, Steven K. Libutti, Irina Lubensky, Peter L. Choyke, David Venzon, W. Marston Linehan

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Purpose: Small renal tumors are frequently detected during the screening of patients with a hereditary type of renal cancer. The development of nonsurgical treatment modalities would greatly improve quality of life in these patients. We present our experience with radio frequency interstitial tissue ablation, a heating device approved by the Food and Drug Administration for treating soft tissue tumors. Materials and Methods: Patients underwent radio frequency interstitial tissue ablation of small renal tumors just before surgical excision. Pathological examination of the renal tumors was done to evaluate the treatment effect. Computerized tomography and renal function testing were performed before and after therapy to evaluate toxicity. Results: Four patients underwent treatment of a total of 14 tumors with the radio frequency interstitial tissue ablation device just before surgical removal of the tumors. All lesions were brown after ablation, in contrast to the normal pink appearance of untreated lesions that were resected. On color Doppler ultrasound blood flow to each tumor evident before was not visualized after treatment. The Wilcoxon rank sum test demonstrated no difference preoperatively and postoperatively in blood urea nitrogen, serum creatinine, creatinine clearance or differential renal function. We identified no toxicity associated with radio frequency interstitial tissue ablation. Of the excised tumors 11 were renal cell carcinoma and 3 fibrotic hemorrhagic cysts. For renal cell carcinoma the treatment effect involved the loss of nuclear detail and nonvisualization of nucleoli. These changes were not observed in any tumors resected without radio frequency interstitial tissue ablation. The treatment effect was noted in 10 of the 11 lesions, and in 1 case the treatment effect involved 35% of the tumor. Conclusions: No toxicity was associated with radio frequency interstitial tissue ablation. Percutaneous treatment of renal tumors is planned to evaluate the treatment effect better and further evaluate toxicity.

Original languageEnglish (US)
Pages (from-to)1424-1427
Number of pages4
JournalJournal of Urology
Volume163
Issue number5
StatePublished - May 2000
Externally publishedYes

Fingerprint

Radio
Kidney
Neoplasms
Therapeutics
Nonparametric Statistics
Renal Cell Carcinoma
Creatinine
Doppler Ultrasonography
Equipment and Supplies
Kidney Neoplasms
Blood Urea Nitrogen
United States Food and Drug Administration
Heating
Cysts
Color
Tomography
Quality of Life

Keywords

  • Carcinoma, renal cell
  • Hyperthermia, induced
  • Kidney

ASJC Scopus subject areas

  • Urology

Cite this

Walther, M. M., Shawker, T. H., Libutti, S. K., Lubensky, I., Choyke, P. L., Venzon, D., & Linehan, W. M. (2000). A phase 2 study of radio frequency interstitial tissue ablation of localized renal tumors. Journal of Urology, 163(5), 1424-1427.

A phase 2 study of radio frequency interstitial tissue ablation of localized renal tumors. / Walther, McClellan M.; Shawker, Thomas H.; Libutti, Steven K.; Lubensky, Irina; Choyke, Peter L.; Venzon, David; Linehan, W. Marston.

In: Journal of Urology, Vol. 163, No. 5, 05.2000, p. 1424-1427.

Research output: Contribution to journalArticle

Walther, MM, Shawker, TH, Libutti, SK, Lubensky, I, Choyke, PL, Venzon, D & Linehan, WM 2000, 'A phase 2 study of radio frequency interstitial tissue ablation of localized renal tumors', Journal of Urology, vol. 163, no. 5, pp. 1424-1427.
Walther MM, Shawker TH, Libutti SK, Lubensky I, Choyke PL, Venzon D et al. A phase 2 study of radio frequency interstitial tissue ablation of localized renal tumors. Journal of Urology. 2000 May;163(5):1424-1427.
Walther, McClellan M. ; Shawker, Thomas H. ; Libutti, Steven K. ; Lubensky, Irina ; Choyke, Peter L. ; Venzon, David ; Linehan, W. Marston. / A phase 2 study of radio frequency interstitial tissue ablation of localized renal tumors. In: Journal of Urology. 2000 ; Vol. 163, No. 5. pp. 1424-1427.
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