A Perspective on Brain-Gut Communication: The American Gastroenterology Association and American Psychosomatic Society Joint Symposium on Brain-gut Interactions and the Intestinal Microenvironment

Olga C. Aroniadis, Douglas A. Drossman, Magnus Simren

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

BACKGROUND: Alterations in brain-gut communication and the intestinal microenvironment have been implicated in a variety of medical and neuropsychiatric diseases. Three central areas require basic and clinical research: (1) how the intestinal microenvironment interacts with the host immune system, central nervous system and enteric nervous system; (2) the role of the intestinal microenvironment in the pathogenesis of medical and neuropsychiatric disease; (3) the effects of diet, prebiotics, probiotics and fecal microbiota transplantation on the intestinal microenvironment and the treatment of disease. METHODS: This review article is based on a symposium convened by the American Gastroenterology Association and American Psychosomatic Society to foster interest in the role of the intestinal microenvironment in brain-gut communication and pathogenesis of neuropsychiatric and biopsychosocial disorders. The aim was to define the stat-of-the-art of the current scientific knowledge base and to identify guidelines and future directions for new research in this area. RESULTS: This review provides a characterization of the intestinal microbial composition and function. We also provide evidence for the interactions between the intestinal microbiome, the host and the environment. The role of the intestinal microbiome in medical and neuropsychiatric diseases is reviewed as well as the treatment effects of manipulation of the intestinal microbiome. CONCLUSIONS: Based on this review, opportunities and challenges for conducting research in the field are described, leading to potential avenues for future research.

Original languageEnglish (US)
JournalPsychosomatic Medicine
DOIs
StateAccepted/In press - Dec 2 2016
Externally publishedYes

Fingerprint

Gastroenterology
Joints
Brain
Research
Enteric Nervous System
Prebiotics
Knowledge Bases
Probiotics
Art
Immune System
Central Nervous System
Guidelines
Diet
Symposium
Interaction
Communication
Therapeutics
Gastrointestinal Microbiome

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Arts and Humanities (miscellaneous)
  • Applied Psychology
  • Psychiatry and Mental health

Cite this

@article{fbfd769f3d3c40929ae4cc5d9eec1105,
title = "A Perspective on Brain-Gut Communication: The American Gastroenterology Association and American Psychosomatic Society Joint Symposium on Brain-gut Interactions and the Intestinal Microenvironment",
abstract = "BACKGROUND: Alterations in brain-gut communication and the intestinal microenvironment have been implicated in a variety of medical and neuropsychiatric diseases. Three central areas require basic and clinical research: (1) how the intestinal microenvironment interacts with the host immune system, central nervous system and enteric nervous system; (2) the role of the intestinal microenvironment in the pathogenesis of medical and neuropsychiatric disease; (3) the effects of diet, prebiotics, probiotics and fecal microbiota transplantation on the intestinal microenvironment and the treatment of disease. METHODS: This review article is based on a symposium convened by the American Gastroenterology Association and American Psychosomatic Society to foster interest in the role of the intestinal microenvironment in brain-gut communication and pathogenesis of neuropsychiatric and biopsychosocial disorders. The aim was to define the stat-of-the-art of the current scientific knowledge base and to identify guidelines and future directions for new research in this area. RESULTS: This review provides a characterization of the intestinal microbial composition and function. We also provide evidence for the interactions between the intestinal microbiome, the host and the environment. The role of the intestinal microbiome in medical and neuropsychiatric diseases is reviewed as well as the treatment effects of manipulation of the intestinal microbiome. CONCLUSIONS: Based on this review, opportunities and challenges for conducting research in the field are described, leading to potential avenues for future research.",
author = "Aroniadis, {Olga C.} and Drossman, {Douglas A.} and Magnus Simren",
year = "2016",
month = "12",
day = "2",
doi = "10.1097/PSY.0000000000000431",
language = "English (US)",
journal = "Psychosomatic Medicine",
issn = "0033-3174",
publisher = "Lippincott Williams and Wilkins",

}

TY - JOUR

T1 - A Perspective on Brain-Gut Communication

T2 - The American Gastroenterology Association and American Psychosomatic Society Joint Symposium on Brain-gut Interactions and the Intestinal Microenvironment

AU - Aroniadis, Olga C.

AU - Drossman, Douglas A.

AU - Simren, Magnus

PY - 2016/12/2

Y1 - 2016/12/2

N2 - BACKGROUND: Alterations in brain-gut communication and the intestinal microenvironment have been implicated in a variety of medical and neuropsychiatric diseases. Three central areas require basic and clinical research: (1) how the intestinal microenvironment interacts with the host immune system, central nervous system and enteric nervous system; (2) the role of the intestinal microenvironment in the pathogenesis of medical and neuropsychiatric disease; (3) the effects of diet, prebiotics, probiotics and fecal microbiota transplantation on the intestinal microenvironment and the treatment of disease. METHODS: This review article is based on a symposium convened by the American Gastroenterology Association and American Psychosomatic Society to foster interest in the role of the intestinal microenvironment in brain-gut communication and pathogenesis of neuropsychiatric and biopsychosocial disorders. The aim was to define the stat-of-the-art of the current scientific knowledge base and to identify guidelines and future directions for new research in this area. RESULTS: This review provides a characterization of the intestinal microbial composition and function. We also provide evidence for the interactions between the intestinal microbiome, the host and the environment. The role of the intestinal microbiome in medical and neuropsychiatric diseases is reviewed as well as the treatment effects of manipulation of the intestinal microbiome. CONCLUSIONS: Based on this review, opportunities and challenges for conducting research in the field are described, leading to potential avenues for future research.

AB - BACKGROUND: Alterations in brain-gut communication and the intestinal microenvironment have been implicated in a variety of medical and neuropsychiatric diseases. Three central areas require basic and clinical research: (1) how the intestinal microenvironment interacts with the host immune system, central nervous system and enteric nervous system; (2) the role of the intestinal microenvironment in the pathogenesis of medical and neuropsychiatric disease; (3) the effects of diet, prebiotics, probiotics and fecal microbiota transplantation on the intestinal microenvironment and the treatment of disease. METHODS: This review article is based on a symposium convened by the American Gastroenterology Association and American Psychosomatic Society to foster interest in the role of the intestinal microenvironment in brain-gut communication and pathogenesis of neuropsychiatric and biopsychosocial disorders. The aim was to define the stat-of-the-art of the current scientific knowledge base and to identify guidelines and future directions for new research in this area. RESULTS: This review provides a characterization of the intestinal microbial composition and function. We also provide evidence for the interactions between the intestinal microbiome, the host and the environment. The role of the intestinal microbiome in medical and neuropsychiatric diseases is reviewed as well as the treatment effects of manipulation of the intestinal microbiome. CONCLUSIONS: Based on this review, opportunities and challenges for conducting research in the field are described, leading to potential avenues for future research.

UR - http://www.scopus.com/inward/record.url?scp=85002251313&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85002251313&partnerID=8YFLogxK

U2 - 10.1097/PSY.0000000000000431

DO - 10.1097/PSY.0000000000000431

M3 - Article

C2 - 27922565

AN - SCOPUS:85002251313

JO - Psychosomatic Medicine

JF - Psychosomatic Medicine

SN - 0033-3174

ER -