A novel replicated association between FXYD6 gene and schizophrenia

Nannan Zhong; Rui Zhang; Chuan Qiu; Han Yan; Robert K. Valenzuela; Huan Zhang; Wanhu Kang; Shemin Lu; Tingwei Guo; Jie Ma

doi:10.1016/j.bbrc.2011.01.005

A novel replicated association between FXYD6 gene and schizophrenia

Nannan Zhong, Rui Zhang, Chuan Qiu, Han Yan, Robert K. Valenzuela, Huan Zhang, Wanhu Kang, Shemin Lu, Tingwei Guo, Jie Ma

Genetics

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

FXYD6 gene is located in chromosome region 11q22-q24 where previous studies have shown an association with schizophrenia. However, the subsequent studies failed to replicate this finding. To investigate the relationship between FXYD6 locus and schizophrenia in Chinese population, we genotyped six single-nucleotide polymorphisms (SNPs) in this region of FXYD6 in 1142 Han Chinese subjects (576 cases and 566 controls), and performed an association analysis. Significant associations with schizophrenia and the marker rs11544201 (P= 0.0028) and the haplotype rs10790212-rs11544201 (global P= 0.005) were found. Our results support that FXYD6 is a susceptibility gene of schizophrenia. Replication of larger samples and functional analysis of FXYD6 are needed.

Original language	English (US)
Pages (from-to)	118-121
Number of pages	4
Journal	Biochemical and Biophysical Research Communications
Volume	405
Issue number	1
DOIs	https://doi.org/10.1016/j.bbrc.2011.01.005
State	Published - Feb 4 2011

Keywords

Association
FXYD6
Haplotype
SNPs
Schizophrenia

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/j.bbrc.2011.01.005

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title = "A novel replicated association between FXYD6 gene and schizophrenia",

abstract = "FXYD6 gene is located in chromosome region 11q22-q24 where previous studies have shown an association with schizophrenia. However, the subsequent studies failed to replicate this finding. To investigate the relationship between FXYD6 locus and schizophrenia in Chinese population, we genotyped six single-nucleotide polymorphisms (SNPs) in this region of FXYD6 in 1142 Han Chinese subjects (576 cases and 566 controls), and performed an association analysis. Significant associations with schizophrenia and the marker rs11544201 (P= 0.0028) and the haplotype rs10790212-rs11544201 (global P= 0.005) were found. Our results support that FXYD6 is a susceptibility gene of schizophrenia. Replication of larger samples and functional analysis of FXYD6 are needed.",

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author = "Nannan Zhong and Rui Zhang and Chuan Qiu and Han Yan and Valenzuela, {Robert K.} and Huan Zhang and Wanhu Kang and Shemin Lu and Tingwei Guo and Jie Ma",

note = "Funding Information: We are deeply grateful to all of the families who participated in this study, as well as to the psychiatrists and mental health workers who helped us with the identification of the families. This work was supported by grants from the National Natural Science Foundation of China (No. 30800618 ), the Ministry of Education, PRC (No. 20090201120062 ), and the President Fundation of Xi{\textquoteright}an Jiaotong University (No. XJJ2008005 ).",

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doi = "10.1016/j.bbrc.2011.01.005",

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AU - Zhong, Nannan

AU - Zhang, Rui

AU - Qiu, Chuan

AU - Yan, Han

AU - Valenzuela, Robert K.

AU - Zhang, Huan

AU - Kang, Wanhu

AU - Lu, Shemin

AU - Guo, Tingwei

AU - Ma, Jie

N1 - Funding Information: We are deeply grateful to all of the families who participated in this study, as well as to the psychiatrists and mental health workers who helped us with the identification of the families. This work was supported by grants from the National Natural Science Foundation of China (No. 30800618 ), the Ministry of Education, PRC (No. 20090201120062 ), and the President Fundation of Xi’an Jiaotong University (No. XJJ2008005 ).

PY - 2011/2/4

Y1 - 2011/2/4

N2 - FXYD6 gene is located in chromosome region 11q22-q24 where previous studies have shown an association with schizophrenia. However, the subsequent studies failed to replicate this finding. To investigate the relationship between FXYD6 locus and schizophrenia in Chinese population, we genotyped six single-nucleotide polymorphisms (SNPs) in this region of FXYD6 in 1142 Han Chinese subjects (576 cases and 566 controls), and performed an association analysis. Significant associations with schizophrenia and the marker rs11544201 (P= 0.0028) and the haplotype rs10790212-rs11544201 (global P= 0.005) were found. Our results support that FXYD6 is a susceptibility gene of schizophrenia. Replication of larger samples and functional analysis of FXYD6 are needed.

AB - FXYD6 gene is located in chromosome region 11q22-q24 where previous studies have shown an association with schizophrenia. However, the subsequent studies failed to replicate this finding. To investigate the relationship between FXYD6 locus and schizophrenia in Chinese population, we genotyped six single-nucleotide polymorphisms (SNPs) in this region of FXYD6 in 1142 Han Chinese subjects (576 cases and 566 controls), and performed an association analysis. Significant associations with schizophrenia and the marker rs11544201 (P= 0.0028) and the haplotype rs10790212-rs11544201 (global P= 0.005) were found. Our results support that FXYD6 is a susceptibility gene of schizophrenia. Replication of larger samples and functional analysis of FXYD6 are needed.

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KW - Schizophrenia

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A novel replicated association between FXYD6 gene and schizophrenia

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Keywords

ASJC Scopus subject areas

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