A novel replicated association between FXYD6 gene and schizophrenia

Nannan Zhong, Rui Zhang, Chuan Qiu, Han Yan, Robert K. Valenzuela, Huan Zhang, Wanhu Kang, Shemin Lu, Tingwei Guo, Jie Ma

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

FXYD6 gene is located in chromosome region 11q22-q24 where previous studies have shown an association with schizophrenia. However, the subsequent studies failed to replicate this finding. To investigate the relationship between FXYD6 locus and schizophrenia in Chinese population, we genotyped six single-nucleotide polymorphisms (SNPs) in this region of FXYD6 in 1142 Han Chinese subjects (576 cases and 566 controls), and performed an association analysis. Significant associations with schizophrenia and the marker rs11544201 (P= 0.0028) and the haplotype rs10790212-rs11544201 (global P= 0.005) were found. Our results support that FXYD6 is a susceptibility gene of schizophrenia. Replication of larger samples and functional analysis of FXYD6 are needed.

Original languageEnglish (US)
Pages (from-to)118-121
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume405
Issue number1
DOIs
StatePublished - Feb 4 2011

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Schizophrenia
Genes
Functional analysis
Chromosomes
Polymorphism
Nucleotides
Haplotypes
Single Nucleotide Polymorphism
Population

Keywords

  • Association
  • FXYD6
  • Haplotype
  • Schizophrenia
  • SNPs

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Molecular Biology

Cite this

Zhong, N., Zhang, R., Qiu, C., Yan, H., Valenzuela, R. K., Zhang, H., ... Ma, J. (2011). A novel replicated association between FXYD6 gene and schizophrenia. Biochemical and Biophysical Research Communications, 405(1), 118-121. https://doi.org/10.1016/j.bbrc.2011.01.005

A novel replicated association between FXYD6 gene and schizophrenia. / Zhong, Nannan; Zhang, Rui; Qiu, Chuan; Yan, Han; Valenzuela, Robert K.; Zhang, Huan; Kang, Wanhu; Lu, Shemin; Guo, Tingwei; Ma, Jie.

In: Biochemical and Biophysical Research Communications, Vol. 405, No. 1, 04.02.2011, p. 118-121.

Research output: Contribution to journalArticle

Zhong, N, Zhang, R, Qiu, C, Yan, H, Valenzuela, RK, Zhang, H, Kang, W, Lu, S, Guo, T & Ma, J 2011, 'A novel replicated association between FXYD6 gene and schizophrenia', Biochemical and Biophysical Research Communications, vol. 405, no. 1, pp. 118-121. https://doi.org/10.1016/j.bbrc.2011.01.005
Zhong, Nannan ; Zhang, Rui ; Qiu, Chuan ; Yan, Han ; Valenzuela, Robert K. ; Zhang, Huan ; Kang, Wanhu ; Lu, Shemin ; Guo, Tingwei ; Ma, Jie. / A novel replicated association between FXYD6 gene and schizophrenia. In: Biochemical and Biophysical Research Communications. 2011 ; Vol. 405, No. 1. pp. 118-121.
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