A novel peritoneum derived vascular prosthesis formed on a latex catheter in an SDF-1 chemokine enriched environment: A pilot study

Rafał Ulczok, Krzysztof Milewski, Jaroslaw Bis, Stefan Samborski, Agata Krauze, Michał Jelonek, Michal Guc, Dominika Smyczek, Michael Aboodi, Adam Maciejewski, Pawel E. Buszman, Andrzej Bochenek, Wojciech Wojakowski, Michal Krejca

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Introduction: Although saphenous vein grafts are widely used conduits for coronary artery bypass graft surgery, their clinical value remains limited due to high failure rates. The aim of the study was to evaluate feasibility, safety, and biocompatibility of peritoneal derived vascular grafts (PDVG) formed on a silicone-coated, latex, Foley catheter in a stromal cell-derived factor (SDF-1)-enriched environment. Methods: Foley catheters were implanted into the parietal wall of 8 sheep. After 21 days the peritoneal cavity was re-opened and the newly formed tissue fragments were harvested. The animals were randomly assigned into: (1) study group in which conduits were incubated in a solution containing SDF-1, (2) control group without SDF-1 incubation. Left carotid arteries were accessed and “end-to-side” anastomoses were performed. Biological materials for histological examination were taken at 4, 7, 10, and 14 days. Results and Conclusions: The study proved safety, feasibility, and biocompatibility of PDVG formed on the basis of a silicone-coated, latex catheter in an SDF-1 chemokine-enriched environment. These biological grafts effectively integrated with the native high-pressure arterial environment in an ovine model and provided favorable vascular profile. The potential clinical value of this technology needs to be further elucidated in long-term preclinical and clinical studies.

Original languageEnglish (US)
Pages (from-to)89-95
Number of pages7
JournalInternational Journal of Artificial Organs
Volume38
Issue number2
DOIs
StatePublished - 2015

Keywords

  • Peritoneum
  • SDF-1 chemokine
  • Sheep
  • Vascular graft

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering

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