A novel nonobstructive intravascular MRI coil: In vivo imaging of experimental atherosclerosis

Stephen G. Worthley, Gérard Helft, Valentin Fuster, Zahi A. Fayad, Meir Shinnar, Lawrence A. Minkoff, Clyde B. Schechter, John T. Fallon, Juan J. Badimon

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Objective - MRI is being used to characterize the composition of atherosclerotic plaques. However, the resolution achievable using surface radiofrequency coils is limited by the signal to noise ratio. We studied the utility of a new intravascular (IV) MRI probe for high-resolution in vivo imaging of atherosclerotic lesions. Methods and Results - Balloon-injured Watanabe heritable hyperlipidemic rabbits served as the experimental model of atherosclerosis. The newly developed IV MRI probe is 1.3 mm in diameter and can be positioned over a guidewire. MRI was performed with both an external phased-array coil and the IV MR coil. MR observations were correlated with histopathology. After MRI, the animals were killed and analysis of agreement between MR and histopathology was performed. The IV MR coil allows aortic images to be obtained with 156 × 156 μm2 in-plane resolution versus 352 × 352 μm2 when used with the external phased-array coil. No significant motion artifacts were noted, despite the continuation of arterial blood flow during image acquisition around the IV probe. The different components of the atherosclerotic lesions (lipid core and fibrous cap) were easily identified. There was an excellent agreement between MRI with the IV coil and histopathology by simple linear regression for both the mean wall thickness (r=0.88, slope 0.82, P<0.0001) and vessel wall area (r=0.86, slope 1.08, P<0.0001). Conclusions - The new nonobstructive design for this intravascular coil provides great promise for additional work in high-resolution MRI characterization of atherosclerotic plaques in vivo. The ability to position the probe with a guidewire allows its placement under fluoroscopic or MRI guidance, whereas its size is compatible with human coronary arteries.

Original languageEnglish (US)
Pages (from-to)346-350
Number of pages5
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume23
Issue number2
DOIs
StatePublished - Feb 1 2003

Fingerprint

Atherosclerotic Plaques
Atherosclerosis
Signal-To-Noise Ratio
Artifacts
Linear Models
Coronary Vessels
Theoretical Models
Rabbits
Lipids

Keywords

  • Atherosclerosis
  • Intravascular
  • MRI

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Worthley, S. G., Helft, G., Fuster, V., Fayad, Z. A., Shinnar, M., Minkoff, L. A., ... Badimon, J. J. (2003). A novel nonobstructive intravascular MRI coil: In vivo imaging of experimental atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 23(2), 346-350. https://doi.org/10.1161/01.ATV.0000053183.08854.A4

A novel nonobstructive intravascular MRI coil : In vivo imaging of experimental atherosclerosis. / Worthley, Stephen G.; Helft, Gérard; Fuster, Valentin; Fayad, Zahi A.; Shinnar, Meir; Minkoff, Lawrence A.; Schechter, Clyde B.; Fallon, John T.; Badimon, Juan J.

In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 23, No. 2, 01.02.2003, p. 346-350.

Research output: Contribution to journalArticle

Worthley, Stephen G. ; Helft, Gérard ; Fuster, Valentin ; Fayad, Zahi A. ; Shinnar, Meir ; Minkoff, Lawrence A. ; Schechter, Clyde B. ; Fallon, John T. ; Badimon, Juan J. / A novel nonobstructive intravascular MRI coil : In vivo imaging of experimental atherosclerosis. In: Arteriosclerosis, Thrombosis, and Vascular Biology. 2003 ; Vol. 23, No. 2. pp. 346-350.
@article{b96512c062124eb8b099a6c3220862af,
title = "A novel nonobstructive intravascular MRI coil: In vivo imaging of experimental atherosclerosis",
abstract = "Objective - MRI is being used to characterize the composition of atherosclerotic plaques. However, the resolution achievable using surface radiofrequency coils is limited by the signal to noise ratio. We studied the utility of a new intravascular (IV) MRI probe for high-resolution in vivo imaging of atherosclerotic lesions. Methods and Results - Balloon-injured Watanabe heritable hyperlipidemic rabbits served as the experimental model of atherosclerosis. The newly developed IV MRI probe is 1.3 mm in diameter and can be positioned over a guidewire. MRI was performed with both an external phased-array coil and the IV MR coil. MR observations were correlated with histopathology. After MRI, the animals were killed and analysis of agreement between MR and histopathology was performed. The IV MR coil allows aortic images to be obtained with 156 × 156 μm2 in-plane resolution versus 352 × 352 μm2 when used with the external phased-array coil. No significant motion artifacts were noted, despite the continuation of arterial blood flow during image acquisition around the IV probe. The different components of the atherosclerotic lesions (lipid core and fibrous cap) were easily identified. There was an excellent agreement between MRI with the IV coil and histopathology by simple linear regression for both the mean wall thickness (r=0.88, slope 0.82, P<0.0001) and vessel wall area (r=0.86, slope 1.08, P<0.0001). Conclusions - The new nonobstructive design for this intravascular coil provides great promise for additional work in high-resolution MRI characterization of atherosclerotic plaques in vivo. The ability to position the probe with a guidewire allows its placement under fluoroscopic or MRI guidance, whereas its size is compatible with human coronary arteries.",
keywords = "Atherosclerosis, Intravascular, MRI",
author = "Worthley, {Stephen G.} and G{\'e}rard Helft and Valentin Fuster and Fayad, {Zahi A.} and Meir Shinnar and Minkoff, {Lawrence A.} and Schechter, {Clyde B.} and Fallon, {John T.} and Badimon, {Juan J.}",
year = "2003",
month = "2",
day = "1",
doi = "10.1161/01.ATV.0000053183.08854.A4",
language = "English (US)",
volume = "23",
pages = "346--350",
journal = "Arteriosclerosis, Thrombosis, and Vascular Biology",
issn = "1079-5642",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - A novel nonobstructive intravascular MRI coil

T2 - In vivo imaging of experimental atherosclerosis

AU - Worthley, Stephen G.

AU - Helft, Gérard

AU - Fuster, Valentin

AU - Fayad, Zahi A.

AU - Shinnar, Meir

AU - Minkoff, Lawrence A.

AU - Schechter, Clyde B.

AU - Fallon, John T.

AU - Badimon, Juan J.

PY - 2003/2/1

Y1 - 2003/2/1

N2 - Objective - MRI is being used to characterize the composition of atherosclerotic plaques. However, the resolution achievable using surface radiofrequency coils is limited by the signal to noise ratio. We studied the utility of a new intravascular (IV) MRI probe for high-resolution in vivo imaging of atherosclerotic lesions. Methods and Results - Balloon-injured Watanabe heritable hyperlipidemic rabbits served as the experimental model of atherosclerosis. The newly developed IV MRI probe is 1.3 mm in diameter and can be positioned over a guidewire. MRI was performed with both an external phased-array coil and the IV MR coil. MR observations were correlated with histopathology. After MRI, the animals were killed and analysis of agreement between MR and histopathology was performed. The IV MR coil allows aortic images to be obtained with 156 × 156 μm2 in-plane resolution versus 352 × 352 μm2 when used with the external phased-array coil. No significant motion artifacts were noted, despite the continuation of arterial blood flow during image acquisition around the IV probe. The different components of the atherosclerotic lesions (lipid core and fibrous cap) were easily identified. There was an excellent agreement between MRI with the IV coil and histopathology by simple linear regression for both the mean wall thickness (r=0.88, slope 0.82, P<0.0001) and vessel wall area (r=0.86, slope 1.08, P<0.0001). Conclusions - The new nonobstructive design for this intravascular coil provides great promise for additional work in high-resolution MRI characterization of atherosclerotic plaques in vivo. The ability to position the probe with a guidewire allows its placement under fluoroscopic or MRI guidance, whereas its size is compatible with human coronary arteries.

AB - Objective - MRI is being used to characterize the composition of atherosclerotic plaques. However, the resolution achievable using surface radiofrequency coils is limited by the signal to noise ratio. We studied the utility of a new intravascular (IV) MRI probe for high-resolution in vivo imaging of atherosclerotic lesions. Methods and Results - Balloon-injured Watanabe heritable hyperlipidemic rabbits served as the experimental model of atherosclerosis. The newly developed IV MRI probe is 1.3 mm in diameter and can be positioned over a guidewire. MRI was performed with both an external phased-array coil and the IV MR coil. MR observations were correlated with histopathology. After MRI, the animals were killed and analysis of agreement between MR and histopathology was performed. The IV MR coil allows aortic images to be obtained with 156 × 156 μm2 in-plane resolution versus 352 × 352 μm2 when used with the external phased-array coil. No significant motion artifacts were noted, despite the continuation of arterial blood flow during image acquisition around the IV probe. The different components of the atherosclerotic lesions (lipid core and fibrous cap) were easily identified. There was an excellent agreement between MRI with the IV coil and histopathology by simple linear regression for both the mean wall thickness (r=0.88, slope 0.82, P<0.0001) and vessel wall area (r=0.86, slope 1.08, P<0.0001). Conclusions - The new nonobstructive design for this intravascular coil provides great promise for additional work in high-resolution MRI characterization of atherosclerotic plaques in vivo. The ability to position the probe with a guidewire allows its placement under fluoroscopic or MRI guidance, whereas its size is compatible with human coronary arteries.

KW - Atherosclerosis

KW - Intravascular

KW - MRI

UR - http://www.scopus.com/inward/record.url?scp=0037324385&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037324385&partnerID=8YFLogxK

U2 - 10.1161/01.ATV.0000053183.08854.A4

DO - 10.1161/01.ATV.0000053183.08854.A4

M3 - Article

C2 - 12588782

AN - SCOPUS:0037324385

VL - 23

SP - 346

EP - 350

JO - Arteriosclerosis, Thrombosis, and Vascular Biology

JF - Arteriosclerosis, Thrombosis, and Vascular Biology

SN - 1079-5642

IS - 2

ER -