A novel 4.1 ezrin radixin moesin (FERM)-containing protein, 'Willin'

Frank J. Gunn-Moore; Gavin I. Welsh; Lissa R. Herron; Frances Brannigan; Kanamarlapudi Venkateswarlu; Stewart Gillespie; Margaret Brandwein-Gensler; Rashna Madan; Jeremy M. Tavaré; Peter J. Brophy; Michael B. Prystowsky; Simon Guild

doi:10.1016/j.febslet.2005.07.097

A novel 4.1 ezrin radixin moesin (FERM)-containing protein, 'Willin'

Frank J. Gunn-Moore, Gavin I. Welsh, Lissa R. Herron, Frances Brannigan, Kanamarlapudi Venkateswarlu, Stewart Gillespie, Margaret Brandwein-Gensler, Rashna Madan, Jeremy M. Tavaré, Peter J. Brophy, Michael B. Prystowsky, Simon Guild

Pathology

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

The 4.1 superfamily of proteins contain a 4.1 Ezrin Radixin Moesin (FERM) domain and are described as linking the cytoskeleton with the plasma membrane. Here, we describe a new FERM domain-containing protein called Willin. Willin has a recognizable FERM domain within its N-terminus and is capable of binding phospholipids. Its intra-cellular distribution can be cytoplasmic or at the plasma membrane where it can co-localize with actin. However, the plasma membrane location of Willin is not influenced by cytochalasin D induced actin disruption but it is induced by the addition of epidermal growth factor.

Original language	English (US)
Pages (from-to)	5089-5094
Number of pages	6
Journal	FEBS Letters
Volume	579
Issue number	22
DOIs	https://doi.org/10.1016/j.febslet.2005.07.097
State	Published - Sep 12 2005

Keywords

4.1 ezrin radixin moesin

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/j.febslet.2005.07.097

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title = "A novel 4.1 ezrin radixin moesin (FERM)-containing protein, 'Willin'",

abstract = "The 4.1 superfamily of proteins contain a 4.1 Ezrin Radixin Moesin (FERM) domain and are described as linking the cytoskeleton with the plasma membrane. Here, we describe a new FERM domain-containing protein called Willin. Willin has a recognizable FERM domain within its N-terminus and is capable of binding phospholipids. Its intra-cellular distribution can be cytoplasmic or at the plasma membrane where it can co-localize with actin. However, the plasma membrane location of Willin is not influenced by cytochalasin D induced actin disruption but it is induced by the addition of epidermal growth factor.",

keywords = "4.1 ezrin radixin moesin",

author = "Gunn-Moore, {Frank J.} and Welsh, {Gavin I.} and Herron, {Lissa R.} and Frances Brannigan and Kanamarlapudi Venkateswarlu and Stewart Gillespie and Margaret Brandwein-Gensler and Rashna Madan and Tavar{\'e}, {Jeremy M.} and Brophy, {Peter J.} and Prystowsky, {Michael B.} and Simon Guild",

note = "Funding Information: We thank the BBSRC for funding to FJGM; MRC program grant funding to J.M.T.; the Maitland-Ramsay PhD fellowship to L.R.H. We also are grateful to Dr. T. Vaughan (University of St. Andrews) for help in obtaining static images and Dr. V. Zaitsev (University of St Andrews) for help in the alignment program. ",

year = "2005",

month = sep,

day = "12",

doi = "10.1016/j.febslet.2005.07.097",

language = "English (US)",

volume = "579",

pages = "5089--5094",

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T1 - A novel 4.1 ezrin radixin moesin (FERM)-containing protein, 'Willin'

AU - Gunn-Moore, Frank J.

AU - Welsh, Gavin I.

AU - Herron, Lissa R.

AU - Brannigan, Frances

AU - Venkateswarlu, Kanamarlapudi

AU - Gillespie, Stewart

AU - Brandwein-Gensler, Margaret

AU - Madan, Rashna

AU - Tavaré, Jeremy M.

AU - Brophy, Peter J.

AU - Prystowsky, Michael B.

AU - Guild, Simon

N1 - Funding Information: We thank the BBSRC for funding to FJGM; MRC program grant funding to J.M.T.; the Maitland-Ramsay PhD fellowship to L.R.H. We also are grateful to Dr. T. Vaughan (University of St. Andrews) for help in obtaining static images and Dr. V. Zaitsev (University of St Andrews) for help in the alignment program.

PY - 2005/9/12

Y1 - 2005/9/12

N2 - The 4.1 superfamily of proteins contain a 4.1 Ezrin Radixin Moesin (FERM) domain and are described as linking the cytoskeleton with the plasma membrane. Here, we describe a new FERM domain-containing protein called Willin. Willin has a recognizable FERM domain within its N-terminus and is capable of binding phospholipids. Its intra-cellular distribution can be cytoplasmic or at the plasma membrane where it can co-localize with actin. However, the plasma membrane location of Willin is not influenced by cytochalasin D induced actin disruption but it is induced by the addition of epidermal growth factor.

AB - The 4.1 superfamily of proteins contain a 4.1 Ezrin Radixin Moesin (FERM) domain and are described as linking the cytoskeleton with the plasma membrane. Here, we describe a new FERM domain-containing protein called Willin. Willin has a recognizable FERM domain within its N-terminus and is capable of binding phospholipids. Its intra-cellular distribution can be cytoplasmic or at the plasma membrane where it can co-localize with actin. However, the plasma membrane location of Willin is not influenced by cytochalasin D induced actin disruption but it is induced by the addition of epidermal growth factor.

KW - 4.1 ezrin radixin moesin

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SN - 0014-5793

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SP - 5089

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JO - FEBS Letters

JF - FEBS Letters

IS - 22

ER -

A novel 4.1 ezrin radixin moesin (FERM)-containing protein, 'Willin'

Abstract

Keywords

ASJC Scopus subject areas

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