A novel 4.1 ezrin radixin moesin (FERM)-containing protein, 'Willin'

Frank J. Gunn-Moore, Gavin I. Welsh, Lissa R. Herron, Frances Brannigan, Kanamarlapudi Venkateswarlu, Stewart Gillespie, Margaret Brandwein-Gensler, Rashna Madan, Jeremy M. Tavaré, Peter J. Brophy, Michael B. Prystowsky, Simon Guild

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

The 4.1 superfamily of proteins contain a 4.1 Ezrin Radixin Moesin (FERM) domain and are described as linking the cytoskeleton with the plasma membrane. Here, we describe a new FERM domain-containing protein called Willin. Willin has a recognizable FERM domain within its N-terminus and is capable of binding phospholipids. Its intra-cellular distribution can be cytoplasmic or at the plasma membrane where it can co-localize with actin. However, the plasma membrane location of Willin is not influenced by cytochalasin D induced actin disruption but it is induced by the addition of epidermal growth factor.

Original languageEnglish (US)
Pages (from-to)5089-5094
Number of pages6
JournalFEBS Letters
Volume579
Issue number22
DOIs
StatePublished - Sep 12 2005

Keywords

  • 4.1 ezrin radixin moesin

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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    Gunn-Moore, F. J., Welsh, G. I., Herron, L. R., Brannigan, F., Venkateswarlu, K., Gillespie, S., Brandwein-Gensler, M., Madan, R., Tavaré, J. M., Brophy, P. J., Prystowsky, M. B., & Guild, S. (2005). A novel 4.1 ezrin radixin moesin (FERM)-containing protein, 'Willin'. FEBS Letters, 579(22), 5089-5094. https://doi.org/10.1016/j.febslet.2005.07.097