A novel 4.1 ezrin radixin moesin (FERM)-containing protein, 'Willin'

Frank J. Gunn-Moore, Gavin I. Welsh, Lissa R. Herron, Frances Brannigan, Kanamarlapudi Venkateswarlu, Stewart Gillespie, Margaret Brandwein-Gensler, Rashna Madan, Jeremy M. Tavaré, Peter J. Brophy, Michael B. Prystowsky, Simon Guild

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The 4.1 superfamily of proteins contain a 4.1 Ezrin Radixin Moesin (FERM) domain and are described as linking the cytoskeleton with the plasma membrane. Here, we describe a new FERM domain-containing protein called Willin. Willin has a recognizable FERM domain within its N-terminus and is capable of binding phospholipids. Its intra-cellular distribution can be cytoplasmic or at the plasma membrane where it can co-localize with actin. However, the plasma membrane location of Willin is not influenced by cytochalasin D induced actin disruption but it is induced by the addition of epidermal growth factor.

Original languageEnglish (US)
Pages (from-to)5089-5094
Number of pages6
JournalFEBS Letters
Volume579
Issue number22
DOIs
StatePublished - Sep 12 2005

Fingerprint

Cell membranes
Cell Membrane
Actins
Cytochalasin D
Proteins
Cytoskeleton
Epidermal Growth Factor
Phospholipids
moesin
radixin
ezrin

Keywords

  • 4.1 ezrin radixin moesin

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Gunn-Moore, F. J., Welsh, G. I., Herron, L. R., Brannigan, F., Venkateswarlu, K., Gillespie, S., ... Guild, S. (2005). A novel 4.1 ezrin radixin moesin (FERM)-containing protein, 'Willin'. FEBS Letters, 579(22), 5089-5094. https://doi.org/10.1016/j.febslet.2005.07.097

A novel 4.1 ezrin radixin moesin (FERM)-containing protein, 'Willin'. / Gunn-Moore, Frank J.; Welsh, Gavin I.; Herron, Lissa R.; Brannigan, Frances; Venkateswarlu, Kanamarlapudi; Gillespie, Stewart; Brandwein-Gensler, Margaret; Madan, Rashna; Tavaré, Jeremy M.; Brophy, Peter J.; Prystowsky, Michael B.; Guild, Simon.

In: FEBS Letters, Vol. 579, No. 22, 12.09.2005, p. 5089-5094.

Research output: Contribution to journalArticle

Gunn-Moore, FJ, Welsh, GI, Herron, LR, Brannigan, F, Venkateswarlu, K, Gillespie, S, Brandwein-Gensler, M, Madan, R, Tavaré, JM, Brophy, PJ, Prystowsky, MB & Guild, S 2005, 'A novel 4.1 ezrin radixin moesin (FERM)-containing protein, 'Willin'', FEBS Letters, vol. 579, no. 22, pp. 5089-5094. https://doi.org/10.1016/j.febslet.2005.07.097
Gunn-Moore FJ, Welsh GI, Herron LR, Brannigan F, Venkateswarlu K, Gillespie S et al. A novel 4.1 ezrin radixin moesin (FERM)-containing protein, 'Willin'. FEBS Letters. 2005 Sep 12;579(22):5089-5094. https://doi.org/10.1016/j.febslet.2005.07.097
Gunn-Moore, Frank J. ; Welsh, Gavin I. ; Herron, Lissa R. ; Brannigan, Frances ; Venkateswarlu, Kanamarlapudi ; Gillespie, Stewart ; Brandwein-Gensler, Margaret ; Madan, Rashna ; Tavaré, Jeremy M. ; Brophy, Peter J. ; Prystowsky, Michael B. ; Guild, Simon. / A novel 4.1 ezrin radixin moesin (FERM)-containing protein, 'Willin'. In: FEBS Letters. 2005 ; Vol. 579, No. 22. pp. 5089-5094.
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