A NOS1 variant implicated in cognitive performance influences evoked neural responses during a high density EEG study of early visual perception

Therese O'Donoghue, Derek W. Morris, Ciara Fahey, Andreia Da Costa, John J. Foxe, Doreen Hoerold, Daniela Tropea, Michael Gill, Aiden Corvin, Gary Donohoe

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: The nitric oxide synthasase-1 gene (NOS1) has been implicated in mental disorders including schizophrenia and variation in cognition. The NOS1 variant rs6490121 identified in a genome wide association study of schizophrenia has recently been associated with variation in general intelligence and working memory in both patients and healthy participants. Whether this variant is also associated with variation in early sensory processing remains unclear. Methods: We investigated differences in the P1 visual evoked potential in a high density EEG study of 54 healthy participants. Given both NOS1's association with cognition and recent evidence that cognitive performance and P1 response are correlated, we investigated whether NOS1's effect on P1 response was independent of its effects on cognition using CANTAB's spatial working memory (SWM) task. Results: We found that carriers of the previously identified risk "G" allele showed significantly lower P1 responses than non-carriers. We also found that while P1 response and SWM performance were correlated, NOS1 continued to explain a significant proportion of variation in P1 response even when its effects on cognition were accounted for. Conclusion: The schizophrenia implicated NOS1 variants rs6490121 influences visual sensory processing as measured by the P1 response, either as part of the gene's pleiotropic effects on multiple aspects of brain function, or because of a primary influence on sensory processing that mediates the effects already seen in higher cognitive processes.

Original languageEnglish (US)
Pages (from-to)1202-1211
Number of pages10
JournalHuman Brain Mapping
Volume33
Issue number5
DOIs
StatePublished - May 2012

Fingerprint

Visual Perception
Cognition
Electroencephalography
Nitric Oxide
Short-Term Memory
Schizophrenia
Genes
Healthy Volunteers
Genetic Pleiotropy
Visual Evoked Potentials
Genome-Wide Association Study
Intelligence
Mental Disorders
Alleles
Brain
Spatial Memory

Keywords

  • NOS1 gene
  • Schizophrenia
  • Visual evoked potentials
  • Working memory

ASJC Scopus subject areas

  • Clinical Neurology
  • Anatomy
  • Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

A NOS1 variant implicated in cognitive performance influences evoked neural responses during a high density EEG study of early visual perception. / O'Donoghue, Therese; Morris, Derek W.; Fahey, Ciara; Costa, Andreia Da; Foxe, John J.; Hoerold, Doreen; Tropea, Daniela; Gill, Michael; Corvin, Aiden; Donohoe, Gary.

In: Human Brain Mapping, Vol. 33, No. 5, 05.2012, p. 1202-1211.

Research output: Contribution to journalArticle

O'Donoghue, T, Morris, DW, Fahey, C, Costa, AD, Foxe, JJ, Hoerold, D, Tropea, D, Gill, M, Corvin, A & Donohoe, G 2012, 'A NOS1 variant implicated in cognitive performance influences evoked neural responses during a high density EEG study of early visual perception', Human Brain Mapping, vol. 33, no. 5, pp. 1202-1211. https://doi.org/10.1002/hbm.21281
O'Donoghue, Therese ; Morris, Derek W. ; Fahey, Ciara ; Costa, Andreia Da ; Foxe, John J. ; Hoerold, Doreen ; Tropea, Daniela ; Gill, Michael ; Corvin, Aiden ; Donohoe, Gary. / A NOS1 variant implicated in cognitive performance influences evoked neural responses during a high density EEG study of early visual perception. In: Human Brain Mapping. 2012 ; Vol. 33, No. 5. pp. 1202-1211.
@article{76ec0f694d4145468cc1ca358d58fe5a,
title = "A NOS1 variant implicated in cognitive performance influences evoked neural responses during a high density EEG study of early visual perception",
abstract = "Background: The nitric oxide synthasase-1 gene (NOS1) has been implicated in mental disorders including schizophrenia and variation in cognition. The NOS1 variant rs6490121 identified in a genome wide association study of schizophrenia has recently been associated with variation in general intelligence and working memory in both patients and healthy participants. Whether this variant is also associated with variation in early sensory processing remains unclear. Methods: We investigated differences in the P1 visual evoked potential in a high density EEG study of 54 healthy participants. Given both NOS1's association with cognition and recent evidence that cognitive performance and P1 response are correlated, we investigated whether NOS1's effect on P1 response was independent of its effects on cognition using CANTAB's spatial working memory (SWM) task. Results: We found that carriers of the previously identified risk {"}G{"} allele showed significantly lower P1 responses than non-carriers. We also found that while P1 response and SWM performance were correlated, NOS1 continued to explain a significant proportion of variation in P1 response even when its effects on cognition were accounted for. Conclusion: The schizophrenia implicated NOS1 variants rs6490121 influences visual sensory processing as measured by the P1 response, either as part of the gene's pleiotropic effects on multiple aspects of brain function, or because of a primary influence on sensory processing that mediates the effects already seen in higher cognitive processes.",
keywords = "NOS1 gene, Schizophrenia, Visual evoked potentials, Working memory",
author = "Therese O'Donoghue and Morris, {Derek W.} and Ciara Fahey and Costa, {Andreia Da} and Foxe, {John J.} and Doreen Hoerold and Daniela Tropea and Michael Gill and Aiden Corvin and Gary Donohoe",
year = "2012",
month = "5",
doi = "10.1002/hbm.21281",
language = "English (US)",
volume = "33",
pages = "1202--1211",
journal = "Human Brain Mapping",
issn = "1065-9471",
publisher = "Wiley-Liss Inc.",
number = "5",

}

TY - JOUR

T1 - A NOS1 variant implicated in cognitive performance influences evoked neural responses during a high density EEG study of early visual perception

AU - O'Donoghue, Therese

AU - Morris, Derek W.

AU - Fahey, Ciara

AU - Costa, Andreia Da

AU - Foxe, John J.

AU - Hoerold, Doreen

AU - Tropea, Daniela

AU - Gill, Michael

AU - Corvin, Aiden

AU - Donohoe, Gary

PY - 2012/5

Y1 - 2012/5

N2 - Background: The nitric oxide synthasase-1 gene (NOS1) has been implicated in mental disorders including schizophrenia and variation in cognition. The NOS1 variant rs6490121 identified in a genome wide association study of schizophrenia has recently been associated with variation in general intelligence and working memory in both patients and healthy participants. Whether this variant is also associated with variation in early sensory processing remains unclear. Methods: We investigated differences in the P1 visual evoked potential in a high density EEG study of 54 healthy participants. Given both NOS1's association with cognition and recent evidence that cognitive performance and P1 response are correlated, we investigated whether NOS1's effect on P1 response was independent of its effects on cognition using CANTAB's spatial working memory (SWM) task. Results: We found that carriers of the previously identified risk "G" allele showed significantly lower P1 responses than non-carriers. We also found that while P1 response and SWM performance were correlated, NOS1 continued to explain a significant proportion of variation in P1 response even when its effects on cognition were accounted for. Conclusion: The schizophrenia implicated NOS1 variants rs6490121 influences visual sensory processing as measured by the P1 response, either as part of the gene's pleiotropic effects on multiple aspects of brain function, or because of a primary influence on sensory processing that mediates the effects already seen in higher cognitive processes.

AB - Background: The nitric oxide synthasase-1 gene (NOS1) has been implicated in mental disorders including schizophrenia and variation in cognition. The NOS1 variant rs6490121 identified in a genome wide association study of schizophrenia has recently been associated with variation in general intelligence and working memory in both patients and healthy participants. Whether this variant is also associated with variation in early sensory processing remains unclear. Methods: We investigated differences in the P1 visual evoked potential in a high density EEG study of 54 healthy participants. Given both NOS1's association with cognition and recent evidence that cognitive performance and P1 response are correlated, we investigated whether NOS1's effect on P1 response was independent of its effects on cognition using CANTAB's spatial working memory (SWM) task. Results: We found that carriers of the previously identified risk "G" allele showed significantly lower P1 responses than non-carriers. We also found that while P1 response and SWM performance were correlated, NOS1 continued to explain a significant proportion of variation in P1 response even when its effects on cognition were accounted for. Conclusion: The schizophrenia implicated NOS1 variants rs6490121 influences visual sensory processing as measured by the P1 response, either as part of the gene's pleiotropic effects on multiple aspects of brain function, or because of a primary influence on sensory processing that mediates the effects already seen in higher cognitive processes.

KW - NOS1 gene

KW - Schizophrenia

KW - Visual evoked potentials

KW - Working memory

UR - http://www.scopus.com/inward/record.url?scp=84859445021&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84859445021&partnerID=8YFLogxK

U2 - 10.1002/hbm.21281

DO - 10.1002/hbm.21281

M3 - Article

C2 - 21520349

AN - SCOPUS:84859445021

VL - 33

SP - 1202

EP - 1211

JO - Human Brain Mapping

JF - Human Brain Mapping

SN - 1065-9471

IS - 5

ER -