A nonhuman primate model of Gilbert's syndrome

O. W. Portman, Jayanta Roy-Chowdhury, N. Roy Chowdhury, M. Alexander, C. E. Cornelius, I. M. Arias

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Abstract

A Bolivian population of squirrel monkeys, Saimiri sciureus, exhibits several features of Gilbert's syndrome in man, and is proposed as a nonhuman primate model of the condition. The Bolivian population was found to have higher fasting (40.6 ± 2.7 μM; mean ± S.E.) and postcibal (9.9 ± 0.9 μM) plasma unconjugated bilirubin concentrations (p < 0.001) than a closely related Brazilian population (fasting 5.5 ± 0.7 μM); postcibal (2.4 ± 0.7 μM). After intravenous administration of [3H]bilirubin as a tracer dose or at 3.4 μmoles per kg body weight, there was delayed plasma clearance in the Bolivian monkeys. Hepatic UDP-glucuronyl transferase activity for bilirubin (164 ± 25 nmoles per 30 min per gm liver) and biliary bilirubin diglucuronide to monoglucuronide ratios (2.9 ± 0.2) were lower in Bolivian monkeys than in Brazilians (421 ± 36 nmoles per 30 min per gm liver - p < 0.01 and 4.1 ± 0.1 - p < 0.02, respectively). Hepatic cytosol glutathione-S-transferase B activity (ligandin) levels were similar for the two populations. After phenobarbital therapy, fasting (11.1 ± 0.9 μM) and postcibal (5.3 ± 1 μM) plasma bilirubin concentrations in Bolivian monkeys were significantly reduced (p < 0.001). Sulfobromophthalein clearance was slightly slower in the Bolivian than in the Brazilian monkeys. SGOT, lactate dehydrogenase, γ-glutamyl transpeptidase and alkaline phosphatase activities were not increased in Bolivians. Fasting serum conjugated bile salt concentrations in Bolivian monkeys were lower than that in Brazilian monkeys (p < 0.01). Erythrocyte survival and hematological measurements were comparable in both populations.

Original languageEnglish (US)
Pages (from-to)175-179
Number of pages5
JournalHepatology
Volume4
Issue number2
StatePublished - 1984

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Gilbert Disease
Primates
Haplorhini
Bilirubin
Fasting
Saimiri
Population
Liver
Glutathione Transferase
Erythrocyte Aging
Sulfobromophthalein
Glucuronosyltransferase
gamma-Glutamyltransferase
Phenobarbital
Aspartate Aminotransferases
Bile Acids and Salts
L-Lactate Dehydrogenase
Intravenous Administration
Cytosol
Alkaline Phosphatase

ASJC Scopus subject areas

  • Hepatology

Cite this

Portman, O. W., Roy-Chowdhury, J., Roy Chowdhury, N., Alexander, M., Cornelius, C. E., & Arias, I. M. (1984). A nonhuman primate model of Gilbert's syndrome. Hepatology, 4(2), 175-179.

A nonhuman primate model of Gilbert's syndrome. / Portman, O. W.; Roy-Chowdhury, Jayanta; Roy Chowdhury, N.; Alexander, M.; Cornelius, C. E.; Arias, I. M.

In: Hepatology, Vol. 4, No. 2, 1984, p. 175-179.

Research output: Contribution to journalArticle

Portman, OW, Roy-Chowdhury, J, Roy Chowdhury, N, Alexander, M, Cornelius, CE & Arias, IM 1984, 'A nonhuman primate model of Gilbert's syndrome', Hepatology, vol. 4, no. 2, pp. 175-179.
Portman OW, Roy-Chowdhury J, Roy Chowdhury N, Alexander M, Cornelius CE, Arias IM. A nonhuman primate model of Gilbert's syndrome. Hepatology. 1984;4(2):175-179.
Portman, O. W. ; Roy-Chowdhury, Jayanta ; Roy Chowdhury, N. ; Alexander, M. ; Cornelius, C. E. ; Arias, I. M. / A nonhuman primate model of Gilbert's syndrome. In: Hepatology. 1984 ; Vol. 4, No. 2. pp. 175-179.
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