A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche

Jlenia Guarnerio, Lourdes Maria Mendez, Noboru Asada, Archita Venugopal Menon, Jacqueline Fung, Kelsey Berry, Paul S. Frenette, Keisuke Ito, Pier Paolo Pandolfi

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5 Scopus citations

Abstract

Disease recurrence after therapy, due to the persistence of resistant leukemic cells, represents a fundamental problem in the treatment of leukemia. Elucidating the mechanisms responsible for the maintenance of leukemic cells, before and after treatment, is therefore critical to identify curative modalities. It has become increasingly clear that cell-autonomous mechanisms are not solely responsible for leukemia maintenance. Here, we report a role for Pml in mesenchymal stem cells (MSCs) in supporting leukemic cells of both CML and AML. Mechanistically, we show that Pml regulates pro-inflammatory cytokines within MSCs, and that this function is critical in sustaining CML-KLS and AML ckit+ leukemic cells non-cell autonomously.

Original languageEnglish (US)
Article number66
JournalNature communications
Volume9
Issue number1
DOIs
StatePublished - Dec 1 2018

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ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Guarnerio, J., Mendez, L. M., Asada, N., Menon, A. V., Fung, J., Berry, K., Frenette, P. S., Ito, K., & Pandolfi, P. P. (2018). A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche. Nature communications, 9(1), [66]. https://doi.org/10.1038/s41467-017-02427-x