A non-apoptotic role for Fas/FasL in erythropoiesis

Graeme W. Carlile, Deborah H. Smith, Martin Wiedmann

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Issues remain to be elucidated in the developmental regulation of erythropoiesis. In particular the role of Fas, a member of the tumor necrosis factor family of receptors despite much work remains unclear. During erythropoiesis, Fas is expressed at low levels on erythroblasts. For most cell types, Fas to FasL interaction causes apoptotic cell death via caspase activation. Here, we show that in humans, early erythroid progenitors are refractory to apoptosis triggered through Fas. Further during early human erythropoiesis, Fas triggered caspase activation provides a positive stimulus for erythroid maturation, and does not alter cellular proliferation or trigger apoptosis.

Original languageEnglish (US)
Pages (from-to)848-854
Number of pages7
JournalFEBS Letters
Volume583
Issue number4
DOIs
StatePublished - Feb 18 2009
Externally publishedYes

Fingerprint

Erythropoiesis
Caspases
Chemical activation
Apoptosis
Cell death
Refractory materials
Erythroblasts
Tumor Necrosis Factor-alpha
Tumor Necrosis Factor Receptors
Cell Death
Cell Proliferation

Keywords

  • Cysteine-aspartic acid protease
  • Development
  • Erythrocyte
  • Fas
  • Regulation

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Genetics
  • Molecular Biology
  • Structural Biology

Cite this

Carlile, G. W., Smith, D. H., & Wiedmann, M. (2009). A non-apoptotic role for Fas/FasL in erythropoiesis. FEBS Letters, 583(4), 848-854. https://doi.org/10.1016/j.febslet.2009.01.047

A non-apoptotic role for Fas/FasL in erythropoiesis. / Carlile, Graeme W.; Smith, Deborah H.; Wiedmann, Martin.

In: FEBS Letters, Vol. 583, No. 4, 18.02.2009, p. 848-854.

Research output: Contribution to journalArticle

Carlile, GW, Smith, DH & Wiedmann, M 2009, 'A non-apoptotic role for Fas/FasL in erythropoiesis', FEBS Letters, vol. 583, no. 4, pp. 848-854. https://doi.org/10.1016/j.febslet.2009.01.047
Carlile, Graeme W. ; Smith, Deborah H. ; Wiedmann, Martin. / A non-apoptotic role for Fas/FasL in erythropoiesis. In: FEBS Letters. 2009 ; Vol. 583, No. 4. pp. 848-854.
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