TY - JOUR
T1 - A nine-month-old boy with regression of milestones and severe constipation
T2 - an unusual case of a large spinal NTRK1 fusion pilocytic astrocytoma
AU - Offenbacher, Rachel
AU - Kobets, Andrew
AU - Dalvi, Nagma
AU - Hsu, Kevin
AU - Chin, Steven
AU - Snuderl, Matija
AU - Levy, Adam
AU - Martin, Allison
N1 - Publisher Copyright:
© 2022, This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.
PY - 2022
Y1 - 2022
N2 - Introduction: Pilocytic astrocytoma, a World Health Organization grade 1 tumor, is the most common brain tumor in children between 5 and 14 years of age and the second most common in children younger than 5 and older than 14. Although classical to the cerebellum and hypothalamic regions, it can also arise in the spinal cord. Larotrectinib, a selective inhibitor of tropomyosin receptor kinase, has been effective in pediatric tumors with NTRK fusion mutations in children as young as 1-month-old. Case: We share the case of a 9-month-old boy who presented with a 4-month history of regression of his milestones and severe constipation who was found to have a large spinal pilocytic astrocytoma with multiple intracranial periventricular lesions.
AB - Introduction: Pilocytic astrocytoma, a World Health Organization grade 1 tumor, is the most common brain tumor in children between 5 and 14 years of age and the second most common in children younger than 5 and older than 14. Although classical to the cerebellum and hypothalamic regions, it can also arise in the spinal cord. Larotrectinib, a selective inhibitor of tropomyosin receptor kinase, has been effective in pediatric tumors with NTRK fusion mutations in children as young as 1-month-old. Case: We share the case of a 9-month-old boy who presented with a 4-month history of regression of his milestones and severe constipation who was found to have a large spinal pilocytic astrocytoma with multiple intracranial periventricular lesions.
KW - Larotrectinib
KW - Pilocytic astrocytoma
UR - http://www.scopus.com/inward/record.url?scp=85138038716&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85138038716&partnerID=8YFLogxK
U2 - 10.1007/s00381-022-05662-w
DO - 10.1007/s00381-022-05662-w
M3 - Article
C2 - 36107222
AN - SCOPUS:85138038716
SN - 0256-7040
JO - Child's Nervous System
JF - Child's Nervous System
ER -