A nine-month-old boy with regression of milestones and severe constipation: an unusual case of a large spinal NTRK1 fusion pilocytic astrocytoma

Rachel Offenbacher, Andrew Kobets, Nagma Dalvi, Kevin Hsu, Steven Chin, Matija Snuderl, Adam Levy, Allison Martin

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Pilocytic astrocytoma, a World Health Organization grade 1 tumor, is the most common brain tumor in children between 5 and 14 years of age and the second most common in children younger than 5 and older than 14. Although classical to the cerebellum and hypothalamic regions, it can also arise in the spinal cord. Larotrectinib, a selective inhibitor of tropomyosin receptor kinase, has been effective in pediatric tumors with NTRK fusion mutations in children as young as 1-month-old. Case: We share the case of a 9-month-old boy who presented with a 4-month history of regression of his milestones and severe constipation who was found to have a large spinal pilocytic astrocytoma with multiple intracranial periventricular lesions.

Original languageEnglish (US)
JournalChild's Nervous System
DOIs
StateAccepted/In press - 2022

Keywords

  • Larotrectinib
  • Pilocytic astrocytoma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

Fingerprint

Dive into the research topics of 'A nine-month-old boy with regression of milestones and severe constipation: an unusual case of a large spinal NTRK1 fusion pilocytic astrocytoma'. Together they form a unique fingerprint.

Cite this