A new vesicular compartment in Encephalitozoon cuniculi

Kaya Ghosh, Edward Nieves, Patrick Keeling, Ann Cali, Louis M. Weiss

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The microsporidia are emerging human and veterinary pathogens known to infect every tissue type and organ system. Their infectious spore possesses a number of peculiar organelles, including the diagnostic polar tube. In a proteomics-driven effort to find novel components of this organelle in the human-pathogenic species Encephalitozoon cuniculi, we unexpectedly discovered a protein which localizes to punctate structures consistent with the appearance of relic mitochondria, or mitosomes. However, this novel protein did not colocalize with ferredoxin, a mitochondrial iron-sulfur cluster protein which shows a similar localization pattern by light microscopy. The distribution pattern of this protein thus suggests either a novel vesicular compartment that is similar to mitosomes in size and distribution, the presence of subdomains or branching architecture within mitosomes, or heterogeneity in the protein composition of E. cuniculi mitosomes.

Original languageEnglish (US)
Pages (from-to)324-328
Number of pages5
JournalMicrobes and Infection
Volume14
Issue number4
DOIs
StatePublished - Apr 1 2012

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Keywords

  • Ferredoxin
  • Microsporidia
  • Mitochondria
  • Mitosome
  • Polar vesicles
  • Proteomics

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Infectious Diseases

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