A new synthesis for antibody-mediated immunity

Arturo Casadevall, Liise-anne Pirofski

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

The view that immunoglobulins function largely by potentiating neutralization, cytotoxicity or phagocytosis is being replaced by a new synthesis whereby antibodies participate in all aspects of the immune response, from protecting the host at the earliest time of encounter with a microbe to later challenges. Perhaps the most transformative concept is that immunoglobulins manifest emergent properties, from their structure and function as individual molecules to their interactions with microbial targets and the host immune system. Given that emergent properties are neither reducible to first principles nor predictable, there is a need for new conceptual approaches for understanding antibody function and mechanisms of antibody immunity.

Original languageEnglish (US)
Pages (from-to)21-28
Number of pages8
JournalNature Immunology
Volume13
Issue number1
DOIs
StatePublished - Jan 2012

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Immunity
Antibodies
Immunoglobulins
Microbial Interactions
Phagocytosis
Immune System

ASJC Scopus subject areas

  • Immunology

Cite this

A new synthesis for antibody-mediated immunity. / Casadevall, Arturo; Pirofski, Liise-anne.

In: Nature Immunology, Vol. 13, No. 1, 01.2012, p. 21-28.

Research output: Contribution to journalArticle

Casadevall, Arturo ; Pirofski, Liise-anne. / A new synthesis for antibody-mediated immunity. In: Nature Immunology. 2012 ; Vol. 13, No. 1. pp. 21-28.
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