A new smoothing model for analyzing array CGH data

Nha Nguyen, Heng Huang, Soontorn Oraintara, An Vo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Array based Comparative Genomic Hybridization (CGH) is a molecular cytogenetic method for the detection of chromosomal imbalances and it has been extensively used for studying copy number alterations in various cancer types. Our method captures both the intrinsic spatial change of genome hybridization intensities, and the physical distance between adjacent probes along a chromosome which are not uniform. In this paper, we introduce a dual-tree complex wavelet transform method with the bivariate shrinkage estimator into array CGH data smoothing study. We tested the proposed method on both simulated data and real data, and the results demonstrated superior performance of our method in comparison with extant methods.

Original languageEnglish (US)
Title of host publicationProceedings of the 7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE
Pages1027-1034
Number of pages8
DOIs
StatePublished - Dec 1 2007
Externally publishedYes
Event7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE - Boston, MA, United States
Duration: Jan 14 2007Jan 17 2007

Publication series

NameProceedings of the 7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE

Other

Other7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE
CountryUnited States
CityBoston, MA
Period1/14/071/17/07

ASJC Scopus subject areas

  • Biotechnology
  • Genetics
  • Bioengineering

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  • Cite this

    Nguyen, N., Huang, H., Oraintara, S., & Vo, A. (2007). A new smoothing model for analyzing array CGH data. In Proceedings of the 7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE (pp. 1027-1034). [4375683] (Proceedings of the 7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE). https://doi.org/10.1109/BIBE.2007.4375683