A new smoothing model for analyzing array CGH data

Nha H. Nguyen, Heng Huang, Soontorn Oraintara, An Vo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Array based Comparative Genomic Hybridization (CGH) is a molecular cytogenetic method for the detection of chromosomal imbalances and it has been extensively used for studying copy number alterations in various cancer types. Our method captures both the intrinsic spatial change of genome hybridization intensities, and the physical distance between adjacent probes along a chromosome which are not uniform. In this paper, we introduce a dual-tree complex wavelet transform method with the bivariate shrinkage estimator into array CGH data smoothing study. We tested the proposed method on both simulated data and real data, and the results demonstrated superior performance of our method in comparison with extant methods.

Original languageEnglish (US)
Title of host publicationProceedings of the 7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE
Pages1027-1034
Number of pages8
DOIs
StatePublished - Dec 1 2007
Externally publishedYes
Event7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE - Boston, MA, United States
Duration: Jan 14 2007Jan 17 2007

Other

Other7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE
CountryUnited States
CityBoston, MA
Period1/14/071/17/07

Fingerprint

Comparative Genomic Hybridization
Chromosomes
Wavelet transforms
Genes
Wavelet Analysis
Cytogenetics
Genome
Neoplasms

ASJC Scopus subject areas

  • Biotechnology
  • Genetics
  • Bioengineering

Cite this

Nguyen, N. H., Huang, H., Oraintara, S., & Vo, A. (2007). A new smoothing model for analyzing array CGH data. In Proceedings of the 7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE (pp. 1027-1034). [4375683] https://doi.org/10.1109/BIBE.2007.4375683

A new smoothing model for analyzing array CGH data. / Nguyen, Nha H.; Huang, Heng; Oraintara, Soontorn; Vo, An.

Proceedings of the 7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE. 2007. p. 1027-1034 4375683.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Nguyen, NH, Huang, H, Oraintara, S & Vo, A 2007, A new smoothing model for analyzing array CGH data. in Proceedings of the 7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE., 4375683, pp. 1027-1034, 7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE, Boston, MA, United States, 1/14/07. https://doi.org/10.1109/BIBE.2007.4375683
Nguyen NH, Huang H, Oraintara S, Vo A. A new smoothing model for analyzing array CGH data. In Proceedings of the 7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE. 2007. p. 1027-1034. 4375683 https://doi.org/10.1109/BIBE.2007.4375683
Nguyen, Nha H. ; Huang, Heng ; Oraintara, Soontorn ; Vo, An. / A new smoothing model for analyzing array CGH data. Proceedings of the 7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE. 2007. pp. 1027-1034
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