A new phenothiazine structural scaffold as inhibitors of bacterial quorum sensing in Vibrio harveyi

Nanting Ni, Gaurav Choudhary, Minyong Li, Binghe Wang

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Quorum sensing has attracted much attention due to its involvement in pathologically relevant events such as biofilm formation, virulence factor production, and sporulation. Inhibitors of quorum sensing are important research tools and potential therapeutic agents. In this paper, we describe a phenothiazine structural scaffold as a new type of quorum sensing inhibitors with IC50 values in the single digit micro molar range in Vibrio harveyi.

Original languageEnglish (US)
Pages (from-to)153-156
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume382
Issue number1
DOIs
StatePublished - Apr 24 2009
Externally publishedYes

Keywords

  • Autoinducer-1
  • Autoinducer-2
  • MM32

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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