A new phenothiazine structural scaffold as inhibitors of bacterial quorum sensing in Vibrio harveyi

Nanting Ni; Gaurav Choudhary; Minyong Li; Binghe Wang

doi:10.1016/j.bbrc.2009.02.157

A new phenothiazine structural scaffold as inhibitors of bacterial quorum sensing in Vibrio harveyi

Nanting Ni, Gaurav Choudhary, Minyong Li, Binghe Wang

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Quorum sensing has attracted much attention due to its involvement in pathologically relevant events such as biofilm formation, virulence factor production, and sporulation. Inhibitors of quorum sensing are important research tools and potential therapeutic agents. In this paper, we describe a phenothiazine structural scaffold as a new type of quorum sensing inhibitors with IC₅₀ values in the single digit micro molar range in Vibrio harveyi.

Original language	English (US)
Pages (from-to)	153-156
Number of pages	4
Journal	Biochemical and Biophysical Research Communications
Volume	382
Issue number	1
DOIs	https://doi.org/10.1016/j.bbrc.2009.02.157
State	Published - Apr 24 2009
Externally published	Yes

Keywords

Autoinducer-1
Autoinducer-2
MM32

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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abstract = "Quorum sensing has attracted much attention due to its involvement in pathologically relevant events such as biofilm formation, virulence factor production, and sporulation. Inhibitors of quorum sensing are important research tools and potential therapeutic agents. In this paper, we describe a phenothiazine structural scaffold as a new type of quorum sensing inhibitors with IC50 values in the single digit micro molar range in Vibrio harveyi.",

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author = "Nanting Ni and Gaurav Choudhary and Minyong Li and Binghe Wang",

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AU - Choudhary, Gaurav

AU - Li, Minyong

AU - Wang, Binghe

N1 - Funding Information: Financial support from the Molecular Basis of Disease program at GSU, Georgia Cancer Coalition, and Georgia Research Alliance is gratefully acknowledged.

PY - 2009/4/24

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AB - Quorum sensing has attracted much attention due to its involvement in pathologically relevant events such as biofilm formation, virulence factor production, and sporulation. Inhibitors of quorum sensing are important research tools and potential therapeutic agents. In this paper, we describe a phenothiazine structural scaffold as a new type of quorum sensing inhibitors with IC50 values in the single digit micro molar range in Vibrio harveyi.

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A new phenothiazine structural scaffold as inhibitors of bacterial quorum sensing in Vibrio harveyi

Abstract

Keywords

ASJC Scopus subject areas

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