A new mouse model for evaluating the immunotherapy of human colorectal cancer

H. Hörig, A. Wainstein, L. Long, D. Kahn, S. Soni, A. Marcus, W. Edelmann, R. Kucherlapati, Winfried Edelmann

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

A new murine model of human colorectal cancer was generated by crossing human carcinoembryonic antigen (CEA) transgenic mice (H2Kb) with adenomatous polyposis coli (Apc1638N) knockout mice (H2Kb). The resulting hybrid mice developed gastrointestinal polyps in 6-8 months that progressed to invasive carcinomas with a similar pattern of dysplasia and CEA expression as observed in human colorectal cancer. These animals exhibited incomplete or partial tolerance to CEA as evidenced by delayed growth of CEA-expressing tumors and the inability to inhibit CEA-specific CTL responses. These results have important implications for understanding the role of CEA-specific immunity in human colon cancer patients and suggest that vaccine strategies targeting CEA may be feasible. This model provides a powerful system for evaluating antigen-specific tumor immunity against spontaneous tumors arising in an orthotopic location and permits evaluation of therapeutic vaccine strategies for human colorectal cancer.

Original languageEnglish (US)
Pages (from-to)8520-8526
Number of pages7
JournalCancer Research
Volume61
Issue number23
StatePublished - Dec 1 2001

Fingerprint

Carcinoembryonic Antigen
Immunotherapy
Colorectal Neoplasms
Immunity
Vaccines
Adenomatous Polyposis Coli
Neoplasm Antigens
Polyps
Knockout Mice
Colonic Neoplasms
Transgenic Mice
Neoplasms
Carcinoma
Growth

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Hörig, H., Wainstein, A., Long, L., Kahn, D., Soni, S., Marcus, A., ... Edelmann, W. (2001). A new mouse model for evaluating the immunotherapy of human colorectal cancer. Cancer Research, 61(23), 8520-8526.

A new mouse model for evaluating the immunotherapy of human colorectal cancer. / Hörig, H.; Wainstein, A.; Long, L.; Kahn, D.; Soni, S.; Marcus, A.; Edelmann, W.; Kucherlapati, R.; Edelmann, Winfried.

In: Cancer Research, Vol. 61, No. 23, 01.12.2001, p. 8520-8526.

Research output: Contribution to journalArticle

Hörig, H, Wainstein, A, Long, L, Kahn, D, Soni, S, Marcus, A, Edelmann, W, Kucherlapati, R & Edelmann, W 2001, 'A new mouse model for evaluating the immunotherapy of human colorectal cancer', Cancer Research, vol. 61, no. 23, pp. 8520-8526.
Hörig H, Wainstein A, Long L, Kahn D, Soni S, Marcus A et al. A new mouse model for evaluating the immunotherapy of human colorectal cancer. Cancer Research. 2001 Dec 1;61(23):8520-8526.
Hörig, H. ; Wainstein, A. ; Long, L. ; Kahn, D. ; Soni, S. ; Marcus, A. ; Edelmann, W. ; Kucherlapati, R. ; Edelmann, Winfried. / A new mouse model for evaluating the immunotherapy of human colorectal cancer. In: Cancer Research. 2001 ; Vol. 61, No. 23. pp. 8520-8526.
@article{6054112e160b4caaa560367075e91a59,
title = "A new mouse model for evaluating the immunotherapy of human colorectal cancer",
abstract = "A new murine model of human colorectal cancer was generated by crossing human carcinoembryonic antigen (CEA) transgenic mice (H2Kb) with adenomatous polyposis coli (Apc1638N) knockout mice (H2Kb). The resulting hybrid mice developed gastrointestinal polyps in 6-8 months that progressed to invasive carcinomas with a similar pattern of dysplasia and CEA expression as observed in human colorectal cancer. These animals exhibited incomplete or partial tolerance to CEA as evidenced by delayed growth of CEA-expressing tumors and the inability to inhibit CEA-specific CTL responses. These results have important implications for understanding the role of CEA-specific immunity in human colon cancer patients and suggest that vaccine strategies targeting CEA may be feasible. This model provides a powerful system for evaluating antigen-specific tumor immunity against spontaneous tumors arising in an orthotopic location and permits evaluation of therapeutic vaccine strategies for human colorectal cancer.",
author = "H. H{\"o}rig and A. Wainstein and L. Long and D. Kahn and S. Soni and A. Marcus and W. Edelmann and R. Kucherlapati and Winfried Edelmann",
year = "2001",
month = "12",
day = "1",
language = "English (US)",
volume = "61",
pages = "8520--8526",
journal = "Cancer Research",
issn = "0008-5472",
publisher = "American Association for Cancer Research Inc.",
number = "23",

}

TY - JOUR

T1 - A new mouse model for evaluating the immunotherapy of human colorectal cancer

AU - Hörig, H.

AU - Wainstein, A.

AU - Long, L.

AU - Kahn, D.

AU - Soni, S.

AU - Marcus, A.

AU - Edelmann, W.

AU - Kucherlapati, R.

AU - Edelmann, Winfried

PY - 2001/12/1

Y1 - 2001/12/1

N2 - A new murine model of human colorectal cancer was generated by crossing human carcinoembryonic antigen (CEA) transgenic mice (H2Kb) with adenomatous polyposis coli (Apc1638N) knockout mice (H2Kb). The resulting hybrid mice developed gastrointestinal polyps in 6-8 months that progressed to invasive carcinomas with a similar pattern of dysplasia and CEA expression as observed in human colorectal cancer. These animals exhibited incomplete or partial tolerance to CEA as evidenced by delayed growth of CEA-expressing tumors and the inability to inhibit CEA-specific CTL responses. These results have important implications for understanding the role of CEA-specific immunity in human colon cancer patients and suggest that vaccine strategies targeting CEA may be feasible. This model provides a powerful system for evaluating antigen-specific tumor immunity against spontaneous tumors arising in an orthotopic location and permits evaluation of therapeutic vaccine strategies for human colorectal cancer.

AB - A new murine model of human colorectal cancer was generated by crossing human carcinoembryonic antigen (CEA) transgenic mice (H2Kb) with adenomatous polyposis coli (Apc1638N) knockout mice (H2Kb). The resulting hybrid mice developed gastrointestinal polyps in 6-8 months that progressed to invasive carcinomas with a similar pattern of dysplasia and CEA expression as observed in human colorectal cancer. These animals exhibited incomplete or partial tolerance to CEA as evidenced by delayed growth of CEA-expressing tumors and the inability to inhibit CEA-specific CTL responses. These results have important implications for understanding the role of CEA-specific immunity in human colon cancer patients and suggest that vaccine strategies targeting CEA may be feasible. This model provides a powerful system for evaluating antigen-specific tumor immunity against spontaneous tumors arising in an orthotopic location and permits evaluation of therapeutic vaccine strategies for human colorectal cancer.

UR - http://www.scopus.com/inward/record.url?scp=0035577329&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035577329&partnerID=8YFLogxK

M3 - Article

C2 - 11731437

AN - SCOPUS:0035577329

VL - 61

SP - 8520

EP - 8526

JO - Cancer Research

JF - Cancer Research

SN - 0008-5472

IS - 23

ER -