A new mouse model for evaluating the immunotherapy of human colorectal cancer

Heidi Hörig, Alberto Wainstein, Li Long, Howard L. Kaufman, Doron Kahn, Sandeep Soni, Akiva Marcus, Howard L. Kaufman, Winfried Edelmann, Raju Kucherlapati

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

A new murine model of human colorectal cancer was generated by crossing human carcinoembryonic antigen (CEA) transgenic mice (H2Kb) with adenomatous polyposis coli (Apc1638N) knockout mice (H2Kb). The resulting hybrid mice developed gastrointestinal polyps in 6-8 months that progressed to invasive carcinomas with a similar pattern of dysplasia and CEA expression as observed in human colorectal cancer. These animals exhibited incomplete or partial tolerance to CEA as evidenced by delayed growth of CEA-expressing tumors and the inability to inhibit CEA-specific CTL responses. These results have important implications for understanding the role of CEA-specific immunity in human colon cancer patients and suggest that vaccine strategies targeting CEA may be feasible. This model provides a powerful system for evaluating antigen-specific tumor immunity against spontaneous tumors arising in an orthotopic location and permits evaluation of therapeutic vaccine strategies for human colorectal cancer.

Original languageEnglish (US)
Pages (from-to)8520-8526
Number of pages7
JournalCancer Research
Volume61
Issue number23
StatePublished - Dec 1 2001

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Hörig, H., Wainstein, A., Long, L., Kaufman, H. L., Kahn, D., Soni, S., Marcus, A., Kaufman, H. L., Edelmann, W., & Kucherlapati, R. (2001). A new mouse model for evaluating the immunotherapy of human colorectal cancer. Cancer Research, 61(23), 8520-8526.