A new Graves disease-susceptibility locus maps to chromosome 20q11.2

Yaron Tomer, Giuseppe Barbesino, David A. Greenberg, Erlinda Concepcion, Terry F. Davies

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

The autoimmune thyroid diseases (AITDs) include two related disorders, graves disease (GD) and Hashimoto thyroiditis, in which perturbations of immune regulation result in an immune attack on the thyroid gland. The AITDS are multifactorial and develop in genetically susceptible individuals. However, the genes responsible for this susceptibility remain unknown. Recently, we initiated a whole-genome linkage study of patients with AITD, in order to identify their susceptibility genes. We studied a data set of 53 multiplex, multigenerational AITD families (323 individuals), using highly polymorphic and densely spaced microsatellite markers (intermarker distance

Original languageEnglish (US)
Pages (from-to)1749-1756
Number of pages8
JournalAmerican Journal of Human Genetics
Volume63
Issue number6
DOIs
StatePublished - 1998

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Graves Disease
Disease Susceptibility
Thyroid Diseases
Autoimmune Diseases
Chromosomes
Hashimoto Disease
Microsatellite Repeats
Genes
Thyroid Gland
Genome

ASJC Scopus subject areas

  • Genetics

Cite this

Tomer, Y., Barbesino, G., Greenberg, D. A., Concepcion, E., & Davies, T. F. (1998). A new Graves disease-susceptibility locus maps to chromosome 20q11.2. American Journal of Human Genetics, 63(6), 1749-1756. https://doi.org/10.1086/302146

A new Graves disease-susceptibility locus maps to chromosome 20q11.2. / Tomer, Yaron; Barbesino, Giuseppe; Greenberg, David A.; Concepcion, Erlinda; Davies, Terry F.

In: American Journal of Human Genetics, Vol. 63, No. 6, 1998, p. 1749-1756.

Research output: Contribution to journalArticle

Tomer, Y, Barbesino, G, Greenberg, DA, Concepcion, E & Davies, TF 1998, 'A new Graves disease-susceptibility locus maps to chromosome 20q11.2', American Journal of Human Genetics, vol. 63, no. 6, pp. 1749-1756. https://doi.org/10.1086/302146
Tomer, Yaron ; Barbesino, Giuseppe ; Greenberg, David A. ; Concepcion, Erlinda ; Davies, Terry F. / A new Graves disease-susceptibility locus maps to chromosome 20q11.2. In: American Journal of Human Genetics. 1998 ; Vol. 63, No. 6. pp. 1749-1756.
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