A new era of studying p53-mediated transcription activation

Wei Li Liu, Robert A. Coleman, Sameer K. Singh

Research output: Contribution to journalReview article

Abstract

To prevent tumorigenesis, p53 stimulates transcription by facilitating the recruitment of the transcription machinery on target gene promoters. Cryo-Electron Microscopy studies on p53-bound RNA Polymerase II (Pol II) reveal that p53 structurally regulates Pol II to affect its DNA binding and elongation, providing new insights into p53-mediated transcriptional regulation.

Original languageEnglish (US)
Pages (from-to)102-107
Number of pages6
JournalTranscription
Volume9
Issue number2
DOIs
StatePublished - Mar 15 2018

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Keywords

  • 3D structure
  • RNA polymerase II
  • cryo-electron microscopy
  • p53
  • transcription activation

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Genetics

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