Abstract
To prevent tumorigenesis, p53 stimulates transcription by facilitating the recruitment of the transcription machinery on target gene promoters. Cryo-Electron Microscopy studies on p53-bound RNA Polymerase II (Pol II) reveal that p53 structurally regulates Pol II to affect its DNA binding and elongation, providing new insights into p53-mediated transcriptional regulation.
Original language | English (US) |
---|---|
Pages (from-to) | 102-107 |
Number of pages | 6 |
Journal | Transcription |
Volume | 9 |
Issue number | 2 |
DOIs | |
State | Published - Mar 15 2018 |
Keywords
- 3D structure
- RNA polymerase II
- cryo-electron microscopy
- p53
- transcription activation
ASJC Scopus subject areas
- Biotechnology
- Biochemistry
- Genetics