TY - JOUR
T1 - A new development in trypanosoma cruzi detection
AU - Tanowitz, Herbert B.
AU - Weiss, Louis M.
N1 - Funding Information:
The work of H.B.T. is supported in part by NIH grant AI124000.
Publisher Copyright:
© Copyright 2017 American Society for Microbiology. All Rights Reserved.
PY - 2017/3
Y1 - 2017/3
N2 - Chagas disease is caused by the parasite Trypanosoma cruzi and is an important cause of morbidity and mortality in areas of Latin America where Chagas disease is endemic and among infected individuals who have migrated to nonendemic areas of North America and Europe. There are many diagnostic tests that are employed in the serological diagnosis of this infection. In this issue of the Journal of Clinical Microbiology, Bautista-López et al. provide characterization of excretory vesicles (EVs) from Vero cells infected with T. cruzi and provide data on the EVs produced by trypomastigotes and amastigotes (N. L. Bautista-López et al., J Clin Microbiol 55:744-758, 2017, https://doi.org/10.1128/JCM.01649-16). Their proteomic study defines potential targets to evaluate for improved diagnostic tests, effects on host cell biology that contribute to the pathogenesis of infection, and vaccine candidates. If any of the EV-Associated proteins identified were to be correlated to cure of infection, this would be a major advance.
AB - Chagas disease is caused by the parasite Trypanosoma cruzi and is an important cause of morbidity and mortality in areas of Latin America where Chagas disease is endemic and among infected individuals who have migrated to nonendemic areas of North America and Europe. There are many diagnostic tests that are employed in the serological diagnosis of this infection. In this issue of the Journal of Clinical Microbiology, Bautista-López et al. provide characterization of excretory vesicles (EVs) from Vero cells infected with T. cruzi and provide data on the EVs produced by trypomastigotes and amastigotes (N. L. Bautista-López et al., J Clin Microbiol 55:744-758, 2017, https://doi.org/10.1128/JCM.01649-16). Their proteomic study defines potential targets to evaluate for improved diagnostic tests, effects on host cell biology that contribute to the pathogenesis of infection, and vaccine candidates. If any of the EV-Associated proteins identified were to be correlated to cure of infection, this would be a major advance.
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U2 - 10.1128/JCM.02353-16
DO - 10.1128/JCM.02353-16
M3 - Article
C2 - 28077696
AN - SCOPUS:85014312675
SN - 0095-1137
VL - 55
SP - 690
EP - 692
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
IS - 3
ER -
