A new development in trypanosoma cruzi detection

Herbert B. Tanowitz, Louis M. Weiss

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Chagas disease is caused by the parasite Trypanosoma cruzi and is an important cause of morbidity and mortality in areas of Latin America where Chagas disease is endemic and among infected individuals who have migrated to nonendemic areas of North America and Europe. There are many diagnostic tests that are employed in the serological diagnosis of this infection. In this issue of the Journal of Clinical Microbiology, Bautista-López et al. provide characterization of excretory vesicles (EVs) from Vero cells infected with T. cruzi and provide data on the EVs produced by trypomastigotes and amastigotes (N. L. Bautista-López et al., J Clin Microbiol 55:744-758, 2017, https://doi.org/10.1128/JCM.01649-16). Their proteomic study defines potential targets to evaluate for improved diagnostic tests, effects on host cell biology that contribute to the pathogenesis of infection, and vaccine candidates. If any of the EV-Associated proteins identified were to be correlated to cure of infection, this would be a major advance.

Original languageEnglish (US)
Pages (from-to)690-692
Number of pages3
JournalJournal of Clinical Microbiology
Volume55
Issue number3
DOIs
StatePublished - Mar 1 2017

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Trypanosoma cruzi
Chagas Disease
Routine Diagnostic Tests
Infection
Vero Cells
Latin America
North America
Microbiology
Proteomics
Cell Biology
Parasites
Vaccines
Morbidity
Mortality
Proteins

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

A new development in trypanosoma cruzi detection. / Tanowitz, Herbert B.; Weiss, Louis M.

In: Journal of Clinical Microbiology, Vol. 55, No. 3, 01.03.2017, p. 690-692.

Research output: Contribution to journalArticle

Tanowitz, Herbert B. ; Weiss, Louis M. / A new development in trypanosoma cruzi detection. In: Journal of Clinical Microbiology. 2017 ; Vol. 55, No. 3. pp. 690-692.
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