TY - JOUR
T1 - A neuroendocrine marker in tissues of the immune system
AU - Angeletti, Ruth Hogue
AU - Hickey, William F.
PY - 1985
Y1 - 1985
N2 - Antibodies to chromogranin, a secretory protein marker for the diffuse neuroendocrine system, were used to analyze rat lymphoreticular tissues by means of immunochemistry and immunohistochemistry. Chromogranin-positive cells were present in spleen, lymph node, thymus, and fetal liver. When these organs were gently dispersed and separated on a Ficoll gradient, the chromogranin- immunoreactive cells became enriched in the dense red-cell pellets. The unexpected distribution of these neuroendocrine cells in all immunologically relevant structures suggests that they may link the nervous and immunological systems.
AB - Antibodies to chromogranin, a secretory protein marker for the diffuse neuroendocrine system, were used to analyze rat lymphoreticular tissues by means of immunochemistry and immunohistochemistry. Chromogranin-positive cells were present in spleen, lymph node, thymus, and fetal liver. When these organs were gently dispersed and separated on a Ficoll gradient, the chromogranin- immunoreactive cells became enriched in the dense red-cell pellets. The unexpected distribution of these neuroendocrine cells in all immunologically relevant structures suggests that they may link the nervous and immunological systems.
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U2 - 10.1126/science.3898368
DO - 10.1126/science.3898368
M3 - Article
C2 - 3898368
AN - SCOPUS:0022403942
SN - 0036-8075
VL - 230
SP - 89
EP - 90
JO - Science
JF - Science
IS - 4721
ER -