A neuroendocrine marker in tissues of the immune system

Ruth Hogue Angeletti, William F. Hickey

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Antibodies to chromogranin, a secretory protein marker for the diffuse neuroendocrine system, were used to analyze rat lymphoreticular tissues by means of immunochemistry and immunohistochemistry. Chromogranin-positive cells were present in spleen, lymph node, thymus, and fetal liver. When these organs were gently dispersed and separated on a Ficoll gradient, the chromogranin- immunoreactive cells became enriched in the dense red-cell pellets. The unexpected distribution of these neuroendocrine cells in all immunologically relevant structures suggests that they may link the nervous and immunological systems.

Original languageEnglish (US)
Pages (from-to)89-90
Number of pages2
JournalScience
Volume230
Issue number4721
StatePublished - 1985
Externally publishedYes

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Chromogranins
Immune System
Immunochemistry
Neuroendocrine Cells
Ficoll
Neurosecretory Systems
Thymus Gland
Nervous System
Spleen
Lymph Nodes
Immunohistochemistry
Antibodies
Liver
Proteins

ASJC Scopus subject areas

  • General

Cite this

Angeletti, R. H., & Hickey, W. F. (1985). A neuroendocrine marker in tissues of the immune system. Science, 230(4721), 89-90.

A neuroendocrine marker in tissues of the immune system. / Angeletti, Ruth Hogue; Hickey, William F.

In: Science, Vol. 230, No. 4721, 1985, p. 89-90.

Research output: Contribution to journalArticle

Angeletti, RH & Hickey, WF 1985, 'A neuroendocrine marker in tissues of the immune system', Science, vol. 230, no. 4721, pp. 89-90.
Angeletti RH, Hickey WF. A neuroendocrine marker in tissues of the immune system. Science. 1985;230(4721):89-90.
Angeletti, Ruth Hogue ; Hickey, William F. / A neuroendocrine marker in tissues of the immune system. In: Science. 1985 ; Vol. 230, No. 4721. pp. 89-90.
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