A neural circuit mechanism for mechanosensory feedback control of ingestion

Dong Yoon Kim, Gyuryang Heo, Minyoo Kim, Hyunseo Kim, Ju Ae Jin, Hyun Kyung Kim, Sieun Jung, Myungmo An, Benjamin H. Ahn, Jong Hwi Park, Han Eol Park, Myungsun Lee, Jung Weon Lee, Gary J. Schwartz, Sung Yon Kim

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Mechanosensory feedback from the digestive tract to the brain is critical for limiting excessive food and water intake, but the underlying gut–brain communication pathways and mechanisms remain poorly understood1–12. Here we show that, in mice, neurons in the parabrachial nucleus that express the prodynorphin gene (hereafter, PBPdyn neurons) monitor the intake of both fluids and solids, using mechanosensory signals that arise from the upper digestive tract. Most individual PBPdyn neurons are activated by ingestion as well as the stimulation of the mouth and stomach, which indicates the representation of integrated sensory signals across distinct parts of the digestive tract. PBPdyn neurons are anatomically connected to the digestive periphery via cranial and spinal pathways; we show that, among these pathways, the vagus nerve conveys stomach-distension signals to PBPdyn neurons. Upon receipt of these signals, these neurons produce aversive and sustained appetite-suppressing signals, which discourages the initiation of feeding and drinking (fully recapitulating the symptoms of gastric distension) in part via signalling to the paraventricular hypothalamus. By contrast, inhibiting the same population of PBPdyn neurons induces overconsumption only if a drive for ingestion exists, which confirms that these neurons mediate negative feedback signalling. Our findings reveal a neural mechanism that underlies the mechanosensory monitoring of ingestion and negative feedback control of intake behaviours upon distension of the digestive tract.

Original languageEnglish (US)
Pages (from-to)376-380
Number of pages5
JournalNature
Volume580
Issue number7803
DOIs
StatePublished - Apr 16 2020

ASJC Scopus subject areas

  • General

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