A nested case-control study of mammographic patterns, breast volume, and breast cancer (New York City, NY, United States)

Ikuko Kato, Clifford Beinart, Alan Bleich, Shaun Su, Mimi Kim, Paolo G. Toniolo

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

The relations of Wolfe mammographic patterns, quantitative mammographic densities, and mammographically estimated breast size to breast cancer risk were investigated prospectively in a case-control study nested in the New York University Women's Health Study, a cohort of 14,291 women in New York City, NY (United States). The archived mammograms of 197 breast cancer cases who were identified during the first 5.5 years of the study and of 521 individually matched controls from the same cohort were retrieved and classified according to Wolfe parenchymal patterns and mammographic densities by two expert radiologists. Breast size and volume were estimated on the mammogram's cranio-caudal projection. In both premenopausal and postmenopausal subjects, the risk of breast cancer increased progressively with increasing density and percent density area. A significantly increased risk was found also for Wolfe pattern DY in premenopausal women and P2 pattern in postmenopausal subjects. In premenopausal women, mammographically determined breast volume and breast height also were associated positively with breast cancer risk. Although the results of the present study confirmed that mammographic parenchymal patterns and densities were important predictors of breast cancer risk, their practical use in screening seems limited due to the high prevalence of high risk patterns.

Original languageEnglish (US)
Pages (from-to)431-438
Number of pages8
JournalCancer Causes and Control
Volume6
Issue number5
DOIs
StatePublished - Sep 1995
Externally publishedYes

Fingerprint

Case-Control Studies
Breast
Breast Neoplasms
Women's Health
Cohort Studies
Breast Density

Keywords

  • Breast cancer
  • breast size
  • females
  • mammographic density
  • United States
  • Wolfe patterns

ASJC Scopus subject areas

  • Oncology
  • Epidemiology
  • Cancer Research

Cite this

A nested case-control study of mammographic patterns, breast volume, and breast cancer (New York City, NY, United States). / Kato, Ikuko; Beinart, Clifford; Bleich, Alan; Su, Shaun; Kim, Mimi; Toniolo, Paolo G.

In: Cancer Causes and Control, Vol. 6, No. 5, 09.1995, p. 431-438.

Research output: Contribution to journalArticle

Kato, Ikuko ; Beinart, Clifford ; Bleich, Alan ; Su, Shaun ; Kim, Mimi ; Toniolo, Paolo G. / A nested case-control study of mammographic patterns, breast volume, and breast cancer (New York City, NY, United States). In: Cancer Causes and Control. 1995 ; Vol. 6, No. 5. pp. 431-438.
@article{03dcae3b06a641a79639ac19992dbcb6,
title = "A nested case-control study of mammographic patterns, breast volume, and breast cancer (New York City, NY, United States)",
abstract = "The relations of Wolfe mammographic patterns, quantitative mammographic densities, and mammographically estimated breast size to breast cancer risk were investigated prospectively in a case-control study nested in the New York University Women's Health Study, a cohort of 14,291 women in New York City, NY (United States). The archived mammograms of 197 breast cancer cases who were identified during the first 5.5 years of the study and of 521 individually matched controls from the same cohort were retrieved and classified according to Wolfe parenchymal patterns and mammographic densities by two expert radiologists. Breast size and volume were estimated on the mammogram's cranio-caudal projection. In both premenopausal and postmenopausal subjects, the risk of breast cancer increased progressively with increasing density and percent density area. A significantly increased risk was found also for Wolfe pattern DY in premenopausal women and P2 pattern in postmenopausal subjects. In premenopausal women, mammographically determined breast volume and breast height also were associated positively with breast cancer risk. Although the results of the present study confirmed that mammographic parenchymal patterns and densities were important predictors of breast cancer risk, their practical use in screening seems limited due to the high prevalence of high risk patterns.",
keywords = "Breast cancer, breast size, females, mammographic density, United States, Wolfe patterns",
author = "Ikuko Kato and Clifford Beinart and Alan Bleich and Shaun Su and Mimi Kim and Toniolo, {Paolo G.}",
year = "1995",
month = "9",
doi = "10.1007/BF00052183",
language = "English (US)",
volume = "6",
pages = "431--438",
journal = "Cancer Causes and Control",
issn = "0957-5243",
publisher = "Springer Netherlands",
number = "5",

}

TY - JOUR

T1 - A nested case-control study of mammographic patterns, breast volume, and breast cancer (New York City, NY, United States)

AU - Kato, Ikuko

AU - Beinart, Clifford

AU - Bleich, Alan

AU - Su, Shaun

AU - Kim, Mimi

AU - Toniolo, Paolo G.

PY - 1995/9

Y1 - 1995/9

N2 - The relations of Wolfe mammographic patterns, quantitative mammographic densities, and mammographically estimated breast size to breast cancer risk were investigated prospectively in a case-control study nested in the New York University Women's Health Study, a cohort of 14,291 women in New York City, NY (United States). The archived mammograms of 197 breast cancer cases who were identified during the first 5.5 years of the study and of 521 individually matched controls from the same cohort were retrieved and classified according to Wolfe parenchymal patterns and mammographic densities by two expert radiologists. Breast size and volume were estimated on the mammogram's cranio-caudal projection. In both premenopausal and postmenopausal subjects, the risk of breast cancer increased progressively with increasing density and percent density area. A significantly increased risk was found also for Wolfe pattern DY in premenopausal women and P2 pattern in postmenopausal subjects. In premenopausal women, mammographically determined breast volume and breast height also were associated positively with breast cancer risk. Although the results of the present study confirmed that mammographic parenchymal patterns and densities were important predictors of breast cancer risk, their practical use in screening seems limited due to the high prevalence of high risk patterns.

AB - The relations of Wolfe mammographic patterns, quantitative mammographic densities, and mammographically estimated breast size to breast cancer risk were investigated prospectively in a case-control study nested in the New York University Women's Health Study, a cohort of 14,291 women in New York City, NY (United States). The archived mammograms of 197 breast cancer cases who were identified during the first 5.5 years of the study and of 521 individually matched controls from the same cohort were retrieved and classified according to Wolfe parenchymal patterns and mammographic densities by two expert radiologists. Breast size and volume were estimated on the mammogram's cranio-caudal projection. In both premenopausal and postmenopausal subjects, the risk of breast cancer increased progressively with increasing density and percent density area. A significantly increased risk was found also for Wolfe pattern DY in premenopausal women and P2 pattern in postmenopausal subjects. In premenopausal women, mammographically determined breast volume and breast height also were associated positively with breast cancer risk. Although the results of the present study confirmed that mammographic parenchymal patterns and densities were important predictors of breast cancer risk, their practical use in screening seems limited due to the high prevalence of high risk patterns.

KW - Breast cancer

KW - breast size

KW - females

KW - mammographic density

KW - United States

KW - Wolfe patterns

UR - http://www.scopus.com/inward/record.url?scp=0029101998&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029101998&partnerID=8YFLogxK

U2 - 10.1007/BF00052183

DO - 10.1007/BF00052183

M3 - Article

C2 - 8547541

AN - SCOPUS:0029101998

VL - 6

SP - 431

EP - 438

JO - Cancer Causes and Control

JF - Cancer Causes and Control

SN - 0957-5243

IS - 5

ER -