A model system for analyzing somatic mutations in Drosophila melanogaster

Ana Maria Garcia, Anastasia Derventzi, Rita Busuttil, R. Brent Calder, Ernesto Perez, Linda Chadwell, Martijn E T Dollé, Martha Lundell, Jan Vijg

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Presently there are no good assays for comparing somatic mutation frequencies and spectra between different vertebrate and invertebrate organisms. Here we describe a new lacZ mutation reporter system in D. melanogaster, which complements existing systems in the mouse. The results obtained with the new model indicate two-to threefold higher frequencies of spontaneous mutations than in the mouse, with most of the mutations characterized as large genome rearrangements.

Original languageEnglish (US)
Pages (from-to)401-403
Number of pages3
JournalNature Methods
Volume4
Issue number5
DOIs
StatePublished - May 2007
Externally publishedYes

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Mutation Rate
Drosophila melanogaster
Mutation
Invertebrates
Vertebrates
Genome

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology
  • Cell Biology

Cite this

Garcia, A. M., Derventzi, A., Busuttil, R., Calder, R. B., Perez, E., Chadwell, L., ... Vijg, J. (2007). A model system for analyzing somatic mutations in Drosophila melanogaster. Nature Methods, 4(5), 401-403. https://doi.org/10.1038/nmeth1027

A model system for analyzing somatic mutations in Drosophila melanogaster. / Garcia, Ana Maria; Derventzi, Anastasia; Busuttil, Rita; Calder, R. Brent; Perez, Ernesto; Chadwell, Linda; Dollé, Martijn E T; Lundell, Martha; Vijg, Jan.

In: Nature Methods, Vol. 4, No. 5, 05.2007, p. 401-403.

Research output: Contribution to journalArticle

Garcia, AM, Derventzi, A, Busuttil, R, Calder, RB, Perez, E, Chadwell, L, Dollé, MET, Lundell, M & Vijg, J 2007, 'A model system for analyzing somatic mutations in Drosophila melanogaster', Nature Methods, vol. 4, no. 5, pp. 401-403. https://doi.org/10.1038/nmeth1027
Garcia AM, Derventzi A, Busuttil R, Calder RB, Perez E, Chadwell L et al. A model system for analyzing somatic mutations in Drosophila melanogaster. Nature Methods. 2007 May;4(5):401-403. https://doi.org/10.1038/nmeth1027
Garcia, Ana Maria ; Derventzi, Anastasia ; Busuttil, Rita ; Calder, R. Brent ; Perez, Ernesto ; Chadwell, Linda ; Dollé, Martijn E T ; Lundell, Martha ; Vijg, Jan. / A model system for analyzing somatic mutations in Drosophila melanogaster. In: Nature Methods. 2007 ; Vol. 4, No. 5. pp. 401-403.
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