A model system for analyzing somatic mutations in Drosophila melanogaster

Ana Maria Garcia, Anastasia Derventzi, Rita Busuttil, R. Brent Calder, Ernesto Perez, Linda Chadwell, Martijn E.T. Dollé, Martha Lundell, Jan Vijg

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Presently there are no good assays for comparing somatic mutation frequencies and spectra between different vertebrate and invertebrate organisms. Here we describe a new lacZ mutation reporter system in D. melanogaster, which complements existing systems in the mouse. The results obtained with the new model indicate two-to threefold higher frequencies of spontaneous mutations than in the mouse, with most of the mutations characterized as large genome rearrangements.

Original languageEnglish (US)
Pages (from-to)401-403
Number of pages3
JournalNature Methods
Volume4
Issue number5
DOIs
StatePublished - May 2007

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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  • Cite this

    Garcia, A. M., Derventzi, A., Busuttil, R., Calder, R. B., Perez, E., Chadwell, L., Dollé, M. E. T., Lundell, M., & Vijg, J. (2007). A model system for analyzing somatic mutations in Drosophila melanogaster. Nature Methods, 4(5), 401-403. https://doi.org/10.1038/nmeth1027