A model for transcription termination by RNA polymerase I

Walter H. Lang, Bernice E. Morrow, Qida Ju, Jonathan R. Warner, Ronald H. Reeder

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

The transcription termination site for yeast RNA polymerase I requires not only an 11 bp binding site for Reb1p, but also about 46 bp of 5′ flanking sequence. We propose that Reb1p bound to its site is part of a pause element, while the 5′ flanking sequence contains a release element. Pausing requires little other than the DNA-binding domain of Reb1p and is not specific for polymerase I. The release element, however, can be polymerase specific. We propose a general model for eukaryotic transcription terminators in which termination occurs when a relatively nonspecific signal induces polymerase to pause in the context of a release element.

Original languageEnglish (US)
Pages (from-to)527-534
Number of pages8
JournalCell
Volume79
Issue number3
DOIs
StatePublished - Nov 4 1994

Fingerprint

RNA Polymerase I
5' Flanking Region
Transcription
Yeast
Yeasts
Binding Sites
DNA

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Lang, W. H., Morrow, B. E., Ju, Q., Warner, J. R., & Reeder, R. H. (1994). A model for transcription termination by RNA polymerase I. Cell, 79(3), 527-534. https://doi.org/10.1016/0092-8674(94)90261-5

A model for transcription termination by RNA polymerase I. / Lang, Walter H.; Morrow, Bernice E.; Ju, Qida; Warner, Jonathan R.; Reeder, Ronald H.

In: Cell, Vol. 79, No. 3, 04.11.1994, p. 527-534.

Research output: Contribution to journalArticle

Lang, WH, Morrow, BE, Ju, Q, Warner, JR & Reeder, RH 1994, 'A model for transcription termination by RNA polymerase I', Cell, vol. 79, no. 3, pp. 527-534. https://doi.org/10.1016/0092-8674(94)90261-5
Lang, Walter H. ; Morrow, Bernice E. ; Ju, Qida ; Warner, Jonathan R. ; Reeder, Ronald H. / A model for transcription termination by RNA polymerase I. In: Cell. 1994 ; Vol. 79, No. 3. pp. 527-534.
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