A model for the initiation and growth of extracellular lipid liposomes in arterial intima

Yongyi Yin, Kwang Hee Lim, Sheldon Weinbaum, Shu Chien, David S. Rumschitzki

Research output: Contribution to journalArticle

Abstract

There is considerable evidence that lipoprotein cholesterol, after crossing the arterial endothelium and entering the intima from the vascular lumen, lodges in extracellular lipid packets (labeled 'liposomes') bound to the extracellular matrix. These liposomes appear to form by occasional attachment of a low-density lipoprotein (LDL) to the intimal matrix and to grow in place mainly by appending available free LDL. The liposome size distributions observed in chronically hypercholesteremic (WHHL) and in short- term cholesterol-fed rabbits are quite different. We propose a hierarchy of simple nucleation-polymerization models to describe liposome formation and growth. Even the simplest of these (with only one adjustable parameter) agrees extremely well with the WHHL data. In contrast, the cholesterol-fed rabbit data seem to result from the short-term nonuniform intimal history of LDL supply, which is a consequence of the focal nature of the transendothelial LDL flow through isolated transient leaky junctions. The same models used for the WHHL data, together with this intimal nonuniformity, superimposed on a slow uniform transendothelial seepage also account very well for this cholesterol-fed rabbit data.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume272
Issue number2 41-2
StatePublished - Feb 1997
Externally publishedYes

Fingerprint

Tunica Intima
LDL Lipoproteins
Liposomes
Lipids
Cholesterol
Growth
Rabbits
Polymerization
Endothelium
Extracellular Matrix

Keywords

  • extracellular matrix
  • lipid binding
  • liposome size distribution

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

A model for the initiation and growth of extracellular lipid liposomes in arterial intima. / Yin, Yongyi; Lim, Kwang Hee; Weinbaum, Sheldon; Chien, Shu; Rumschitzki, David S.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 272, No. 2 41-2, 02.1997.

Research output: Contribution to journalArticle

Yin, Yongyi ; Lim, Kwang Hee ; Weinbaum, Sheldon ; Chien, Shu ; Rumschitzki, David S. / A model for the initiation and growth of extracellular lipid liposomes in arterial intima. In: American Journal of Physiology - Heart and Circulatory Physiology. 1997 ; Vol. 272, No. 2 41-2.
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