A mink-HERG complex regulates the cardiac potassium current/(Kr)

Thomas V. McDonald, Zhihui Yu, Zhen Ming, Eugen C. Palma, Marian B. Meyers, Ke Wei Wang, Steve A N Goldstein, Glenn I. Fishman

Research output: Contribution to journalArticle

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Abstract

MinK is a widely expressed protein of relative molecular mass ~15K that forms potassium channels by aggregation with other membrane proteins. Mink governs ion channel activation regulation by second messengers, and the function and structure of the ion conduction pathway. Association of mink with a channel protein known as KvLQTI produces a voltage-gated outward K+ current (I(sK)) resembling the slow cardiac repolarization current (I(Ks)). HERG, a human homologue of the ether-ago-go gene of the fruitfly Drosophila melanogaster, encodes a protein that produces the rapidly activating cardiac delayed rectifier (I(Kr)). These two potassium currents, I(Ks) and I(Kp) provide the principal repolarizing currents in cardiac myocytes for the termination of action potentials. Although hetero1ogously expressed HERG channels are largely indistinguishable from native cardiac I(Kp) a role for mink in this current is suggested by the diminished I(Kr) in an atrial tumour line subjected to mink antisense suppression. Here we show that HERG and mink form a stable complex, and that this heteromultimerization regulates I(Kr) activity. MinK, through the formation of heteromeric channel complexes, is thus central to the control of the heart rate and rhythm.

Original languageEnglish (US)
Pages (from-to)289-292
Number of pages4
JournalNature
Volume388
Issue number6639
DOIs
StatePublished - 1997

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Mink
Potassium
Proteins
Potassium Channels
Second Messenger Systems
Drosophila melanogaster
Ion Channels
Cardiac Myocytes
Ether
Action Potentials
Membrane Proteins
Heart Rate
Ions
Genes

ASJC Scopus subject areas

  • General

Cite this

McDonald, T. V., Yu, Z., Ming, Z., Palma, E. C., Meyers, M. B., Wang, K. W., ... Fishman, G. I. (1997). A mink-HERG complex regulates the cardiac potassium current/(Kr). Nature, 388(6639), 289-292. https://doi.org/10.1038/40882

A mink-HERG complex regulates the cardiac potassium current/(Kr). / McDonald, Thomas V.; Yu, Zhihui; Ming, Zhen; Palma, Eugen C.; Meyers, Marian B.; Wang, Ke Wei; Goldstein, Steve A N; Fishman, Glenn I.

In: Nature, Vol. 388, No. 6639, 1997, p. 289-292.

Research output: Contribution to journalArticle

McDonald, TV, Yu, Z, Ming, Z, Palma, EC, Meyers, MB, Wang, KW, Goldstein, SAN & Fishman, GI 1997, 'A mink-HERG complex regulates the cardiac potassium current/(Kr)', Nature, vol. 388, no. 6639, pp. 289-292. https://doi.org/10.1038/40882
McDonald TV, Yu Z, Ming Z, Palma EC, Meyers MB, Wang KW et al. A mink-HERG complex regulates the cardiac potassium current/(Kr). Nature. 1997;388(6639):289-292. https://doi.org/10.1038/40882
McDonald, Thomas V. ; Yu, Zhihui ; Ming, Zhen ; Palma, Eugen C. ; Meyers, Marian B. ; Wang, Ke Wei ; Goldstein, Steve A N ; Fishman, Glenn I. / A mink-HERG complex regulates the cardiac potassium current/(Kr). In: Nature. 1997 ; Vol. 388, No. 6639. pp. 289-292.
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