A mild preparation of substituted indolizines and indole from simple aromatic precursors using (trimethylsilyl)diazomethane

Liusheng Zhu; Marc Vimolratana; Sean P. Brown; Julio C. Medina

doi:10.1016/j.tetlet.2008.01.067

A mild preparation of substituted indolizines and indole from simple aromatic precursors using (trimethylsilyl)diazomethane

Liusheng Zhu, Marc Vimolratana, Sean P. Brown, Julio C. Medina

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

A mild and convenient synthesis of substituted indolizines from readily available 2-(pyridin-2-yl)acetyl derivatives using (trimethylsilyl)diazomethane is described. The extension of this methodology to the synthesis of indole from 2-aminobenzaldehyde is also reported.

Original language	English (US)
Pages (from-to)	1768-1770
Number of pages	3
Journal	Tetrahedron Letters
Volume	49
Issue number	11
DOIs	https://doi.org/10.1016/j.tetlet.2008.01.067
State	Published - Mar 10 2008
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2008.01.067

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title = "A mild preparation of substituted indolizines and indole from simple aromatic precursors using (trimethylsilyl)diazomethane",

abstract = "A mild and convenient synthesis of substituted indolizines from readily available 2-(pyridin-2-yl)acetyl derivatives using (trimethylsilyl)diazomethane is described. The extension of this methodology to the synthesis of indole from 2-aminobenzaldehyde is also reported.",

author = "Liusheng Zhu and Marc Vimolratana and Brown, {Sean P.} and Medina, {Julio C.}",

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T1 - A mild preparation of substituted indolizines and indole from simple aromatic precursors using (trimethylsilyl)diazomethane

AU - Zhu, Liusheng

AU - Vimolratana, Marc

AU - Brown, Sean P.

AU - Medina, Julio C.

PY - 2008/3/10

Y1 - 2008/3/10

N2 - A mild and convenient synthesis of substituted indolizines from readily available 2-(pyridin-2-yl)acetyl derivatives using (trimethylsilyl)diazomethane is described. The extension of this methodology to the synthesis of indole from 2-aminobenzaldehyde is also reported.

AB - A mild and convenient synthesis of substituted indolizines from readily available 2-(pyridin-2-yl)acetyl derivatives using (trimethylsilyl)diazomethane is described. The extension of this methodology to the synthesis of indole from 2-aminobenzaldehyde is also reported.

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M3 - Article

AN - SCOPUS:38949109341

SN - 0040-4039

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SP - 1768

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 11

ER -

A mild preparation of substituted indolizines and indole from simple aromatic precursors using (trimethylsilyl)diazomethane

Abstract

ASJC Scopus subject areas

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