A meta-analysis of genome-wide association studies of asthma in Puerto Ricans

Qi Yan, John Brehm, Maria Pino-Yanes, Erick Forno, Jerome Lin, Sam S. Oh, Edna Acosta-Perez, Cathy C. Laurie, Michelle M. Cloutier, Benjamin A. Raby, Adrienne M. Stilp, Tamar Sofer, Donglei Hu, Scott Huntsman, Celeste S. Eng, Matthew P. Conomos, Deepa Rastogi, Kenneth Rice, Glorisa Canino, Wei ChenR. Graham Barr, Esteban G. Burchard, Juan C. Celedón

Research output: Contribution to journalArticle

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Abstract

Puerto Ricans are disproportionately affected with asthma in the USA. In this study, we aim to identify genetic variants that confer susceptibility to asthma in Puerto Ricans. We conducted a meta-analysis of genome-wide association studies (GWAS) of asthma in Puerto Ricans, including participants from: the Genetics of Asthma in Latino Americans (GALA) I-II, the Hartford - Puerto Rico Study and the Hispanic Community Health Study. Moreover, we examined whether susceptibility loci identified in previous meta-analyses of GWAS are associated with asthma in Puerto Ricans. The only locus to achieve genome-wide significance was chromosome 17q21, as evidenced by our top single nucleotide polymorphism (SNP), rs907092 (OR 0.71, p=1.2×10-12) at IKZF3. Similar to results in non-Puerto Ricans, SNPs in genes in the same linkage disequilibrium block as IKZF3 (e.g. ZPBP2, ORMDL3 and GSDMB) were significantly associated with asthma in Puerto Ricans. With regard to results from a meta-analysis in Europeans, we replicated findings for rs2305480 at GSDMB, but not for SNPs in any other genes. On the other hand, we replicated results from a meta-analysis of North American populations for SNPs at IL1RL1, TSLP and GSDMB but not for IL33. Our findings suggest that common variants on chromosome 17q21 have the greatest effects on asthma in Puerto Ricans.

Original languageEnglish (US)
Article number1601505
JournalEuropean Respiratory Journal
Volume49
Issue number5
DOIs
StatePublished - May 1 2017

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Genome-Wide Association Study
Hispanic Americans
Meta-Analysis
Asthma
Single Nucleotide Polymorphism
Chromosomes
Puerto Rico
Linkage Disequilibrium
Genes
Genome
Health
Population

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Yan, Q., Brehm, J., Pino-Yanes, M., Forno, E., Lin, J., Oh, S. S., ... Celedón, J. C. (2017). A meta-analysis of genome-wide association studies of asthma in Puerto Ricans. European Respiratory Journal, 49(5), [1601505]. https://doi.org/10.1183/13993003.01505-2016

A meta-analysis of genome-wide association studies of asthma in Puerto Ricans. / Yan, Qi; Brehm, John; Pino-Yanes, Maria; Forno, Erick; Lin, Jerome; Oh, Sam S.; Acosta-Perez, Edna; Laurie, Cathy C.; Cloutier, Michelle M.; Raby, Benjamin A.; Stilp, Adrienne M.; Sofer, Tamar; Hu, Donglei; Huntsman, Scott; Eng, Celeste S.; Conomos, Matthew P.; Rastogi, Deepa; Rice, Kenneth; Canino, Glorisa; Chen, Wei; Barr, R. Graham; Burchard, Esteban G.; Celedón, Juan C.

In: European Respiratory Journal, Vol. 49, No. 5, 1601505, 01.05.2017.

Research output: Contribution to journalArticle

Yan, Q, Brehm, J, Pino-Yanes, M, Forno, E, Lin, J, Oh, SS, Acosta-Perez, E, Laurie, CC, Cloutier, MM, Raby, BA, Stilp, AM, Sofer, T, Hu, D, Huntsman, S, Eng, CS, Conomos, MP, Rastogi, D, Rice, K, Canino, G, Chen, W, Barr, RG, Burchard, EG & Celedón, JC 2017, 'A meta-analysis of genome-wide association studies of asthma in Puerto Ricans', European Respiratory Journal, vol. 49, no. 5, 1601505. https://doi.org/10.1183/13993003.01505-2016
Yan, Qi ; Brehm, John ; Pino-Yanes, Maria ; Forno, Erick ; Lin, Jerome ; Oh, Sam S. ; Acosta-Perez, Edna ; Laurie, Cathy C. ; Cloutier, Michelle M. ; Raby, Benjamin A. ; Stilp, Adrienne M. ; Sofer, Tamar ; Hu, Donglei ; Huntsman, Scott ; Eng, Celeste S. ; Conomos, Matthew P. ; Rastogi, Deepa ; Rice, Kenneth ; Canino, Glorisa ; Chen, Wei ; Barr, R. Graham ; Burchard, Esteban G. ; Celedón, Juan C. / A meta-analysis of genome-wide association studies of asthma in Puerto Ricans. In: European Respiratory Journal. 2017 ; Vol. 49, No. 5.
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