A medullary inhibitory region for trigeminal motoneurons in the cat

Pablo Castillo; Cristina Pedroarena; Michael H. Chase; Francisco R. Morales

doi:10.1016/0006-8993(91)90480-J

A medullary inhibitory region for trigeminal motoneurons in the cat

Pablo Castillo, Cristina Pedroarena, Michael H. Chase, Francisco R. Morales

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

The present report describes the effects on trigeminal motoneurons of stimulation of a circumscribed site within the parvocellular region of the medullary reticular formation. This medullary site was selected because anatomical studies have shown that premotor interneurons project from this site to the trigeminal motorpool^10,13. Electrical stimulation of this site induced IPSPs(PcRF-IPSPs) in jaw-closer motoneurons. A population of these IPSPs, recorded contralateral to the site of stimulation, exhibited latencies shorter than 1.5 ms (mean 1.16±0.08 SD). Their mean amplitude was 1.72 mV ± 1.13 SD and their mean duration was 3.52 ms ± 2.15 SD. We believe that these PcRF-IPSPs arose as the result of activation of a monosynaptic pathway. A comparable inhibitory input from this site to ipsilateral jaw-closer motoneurons and to both contra and ipsilateral digastric motoneurons was also observed. We therefore conclude that this medullary PcRF site contains premotor interneurons that are capable of postsynaptically inhibiting motoneurons that innervate antagonistic jaw muscles.

Original language	English (US)
Pages (from-to)	346-349
Number of pages	4
Journal	Brain research
Volume	549
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(91)90480-J
State	Published - May 24 1991
Externally published	Yes

Keywords

Inhibition
Monosynaptic
Motoneuron
Parvocellularis
Reticular formation
Trigeminal

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(91)90480-J

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title = "A medullary inhibitory region for trigeminal motoneurons in the cat",

abstract = "The present report describes the effects on trigeminal motoneurons of stimulation of a circumscribed site within the parvocellular region of the medullary reticular formation. This medullary site was selected because anatomical studies have shown that premotor interneurons project from this site to the trigeminal motorpool10,13. Electrical stimulation of this site induced IPSPs(PcRF-IPSPs) in jaw-closer motoneurons. A population of these IPSPs, recorded contralateral to the site of stimulation, exhibited latencies shorter than 1.5 ms (mean 1.16±0.08 SD). Their mean amplitude was 1.72 mV ± 1.13 SD and their mean duration was 3.52 ms ± 2.15 SD. We believe that these PcRF-IPSPs arose as the result of activation of a monosynaptic pathway. A comparable inhibitory input from this site to ipsilateral jaw-closer motoneurons and to both contra and ipsilateral digastric motoneurons was also observed. We therefore conclude that this medullary PcRF site contains premotor interneurons that are capable of postsynaptically inhibiting motoneurons that innervate antagonistic jaw muscles.",

keywords = "Inhibition, Monosynaptic, Motoneuron, Parvocellularis, Reticular formation, Trigeminal",

author = "Pablo Castillo and Cristina Pedroarena and Chase, {Michael H.} and Morales, {Francisco R.}",

note = "Funding Information: We are especially grateful to Gabriela Gualco and Nora Macadar for their histological assistance and to Kerch Engelhardt for critically reviewing this manuscript. This work was supported in part by PHS Grant NS 09999.",

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T1 - A medullary inhibitory region for trigeminal motoneurons in the cat

AU - Castillo, Pablo

AU - Pedroarena, Cristina

AU - Chase, Michael H.

AU - Morales, Francisco R.

N1 - Funding Information: We are especially grateful to Gabriela Gualco and Nora Macadar for their histological assistance and to Kerch Engelhardt for critically reviewing this manuscript. This work was supported in part by PHS Grant NS 09999.

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Y1 - 1991/5/24

N2 - The present report describes the effects on trigeminal motoneurons of stimulation of a circumscribed site within the parvocellular region of the medullary reticular formation. This medullary site was selected because anatomical studies have shown that premotor interneurons project from this site to the trigeminal motorpool10,13. Electrical stimulation of this site induced IPSPs(PcRF-IPSPs) in jaw-closer motoneurons. A population of these IPSPs, recorded contralateral to the site of stimulation, exhibited latencies shorter than 1.5 ms (mean 1.16±0.08 SD). Their mean amplitude was 1.72 mV ± 1.13 SD and their mean duration was 3.52 ms ± 2.15 SD. We believe that these PcRF-IPSPs arose as the result of activation of a monosynaptic pathway. A comparable inhibitory input from this site to ipsilateral jaw-closer motoneurons and to both contra and ipsilateral digastric motoneurons was also observed. We therefore conclude that this medullary PcRF site contains premotor interneurons that are capable of postsynaptically inhibiting motoneurons that innervate antagonistic jaw muscles.

AB - The present report describes the effects on trigeminal motoneurons of stimulation of a circumscribed site within the parvocellular region of the medullary reticular formation. This medullary site was selected because anatomical studies have shown that premotor interneurons project from this site to the trigeminal motorpool10,13. Electrical stimulation of this site induced IPSPs(PcRF-IPSPs) in jaw-closer motoneurons. A population of these IPSPs, recorded contralateral to the site of stimulation, exhibited latencies shorter than 1.5 ms (mean 1.16±0.08 SD). Their mean amplitude was 1.72 mV ± 1.13 SD and their mean duration was 3.52 ms ± 2.15 SD. We believe that these PcRF-IPSPs arose as the result of activation of a monosynaptic pathway. A comparable inhibitory input from this site to ipsilateral jaw-closer motoneurons and to both contra and ipsilateral digastric motoneurons was also observed. We therefore conclude that this medullary PcRF site contains premotor interneurons that are capable of postsynaptically inhibiting motoneurons that innervate antagonistic jaw muscles.

KW - Inhibition

KW - Monosynaptic

KW - Motoneuron

KW - Parvocellularis

KW - Reticular formation

KW - Trigeminal

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A medullary inhibitory region for trigeminal motoneurons in the cat

Abstract

Keywords

ASJC Scopus subject areas

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